Development and initial validation of a traditional Chinese medicine symptom-specific outcome measure: a Zheng-related atopic dermatitis symptom questionnaire (ZRADSQ)
机构：[1]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.广东省中医院[2]Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada.[3]Beijing Aerospace General Hospital, Beijing, China.[4]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, PO Box 510120, Guangzhou, China.大德路总院广东省中医院深圳市中医院深圳医学信息中心
Background: Zheng represents pattern differentiation in Traditional Chinese Medicine (TCM), as the basic unit and a key concept in TCM therapeutic theory, is based on the physiology and pathology of TCM. None of the outcome measurements of atopic dermatitis (AD) are Zheng-specific. The effectiveness of TCM is likely to be underestimated without a Zheng-related symptom-specific instrument. The aim of this study was to develop an instrument for measuring the Zheng-related symptom-specific status of patients with AD. Methods: We followed standard methodology to develop the instrument, including item generation and selection, item reduction and presentation, and pretesting, and recruited 188 patients with AD involved in a six-center randomized-controlled trial (ChiCTR-TRC-08000156) to validate the questionnaire. We conducted construct validity, reliability, and responsiveness analysis. The standardized effect size (SES) and standardized response mean (SRM) were used to calculate the responsiveness of additional items and the total score for the rating items. Results: ZRADSQ has 15 items, with 12 rating items and 3 additional items. The 12 rating items fall within three domains: AD symptoms (n = 6 items); Heat (n = 4 items) and Mood (n = 2 items). Confirmatory factor analysis provided good support for a three-factor model (d.f. = 51, x(2)=97.11, RMSEA = 0.07, CFI = 0.96), and the Pearson's correlation coefficient between ZRADSQ and Severity Scoring of Atopic Dermatitis (SCORAD) was 0.40 (P < 0.001). The reliability was also good, with a Cronbach's alpha value for ZRADSQ of 0.84, a split-half coefficient of 0.75, and a test-retest reliability coefficient of 0.98. The standardized effect size and standardized response mean were close to or larger than 1, which indicated moderate to good responsiveness. Conclusions: The ZRADSQ demonstrates promising reliability, validity, and responsiveness. It can be used to determine whether Zheng-specific or symptom-specific treatments relieve the symptom that is most bothersome the patient.
基金：
This study is partly supported by National Technology Supporting Program
during the 11th Five-Year Plan Period(2007BA120B048), National Basic
Research Program of China (2011CB505404); Scientific Research Project of
Public Welfare Industry, State Administration of Traditional Chinese Medicine
of P. R. of China (No. 200707004); Science and Technology Planning Project
of Guangdong Province, China (2011B031700077).
基金编号：2007BA120B048
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|3 区医学
小类|3 区卫生保健与服务
最新[2025]版：
大类|2 区医学
小类|2 区卫生保健与服务2 区卫生政策与服务
JCR分区：
出版当年[2011]版：
Q2HEALTH POLICY & SERVICESQ2HEALTH CARE SCIENCES & SERVICES
最新[2023]版：
Q1HEALTH CARE SCIENCES & SERVICESQ1HEALTH POLICY & SERVICES
第一作者机构：[1]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.[2]Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada.
通讯作者：
通讯机构：[1]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.[4]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, PO Box 510120, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Darong Wu,Chujun Huang,Xiumei Mo,et al.Development and initial validation of a traditional Chinese medicine symptom-specific outcome measure: a Zheng-related atopic dermatitis symptom questionnaire (ZRADSQ)[J].HEALTH AND QUALITY OF LIFE OUTCOMES.2013,11:doi:10.1186/1477-7525-11-212.
APA：
Darong Wu,Chujun Huang,Xiumei Mo,Junfeng Liu,Jianxiong Cai...&Dacan Chen.(2013).Development and initial validation of a traditional Chinese medicine symptom-specific outcome measure: a Zheng-related atopic dermatitis symptom questionnaire (ZRADSQ).HEALTH AND QUALITY OF LIFE OUTCOMES,11,
MLA：
Darong Wu,et al."Development and initial validation of a traditional Chinese medicine symptom-specific outcome measure: a Zheng-related atopic dermatitis symptom questionnaire (ZRADSQ)".HEALTH AND QUALITY OF LIFE OUTCOMES 11.(2013)
