To evaluate the effects of abdominal acupuncture on malignant bone cancer patients' quality of life (QOL) during chemotherapy with Shenque qi distribution therapy, a randomized cross controlled trial was adopted. A total sample of 26 cases were randomly assigned to Group A and Group B for the treatment, as well as evaluated QOL(by EORTC QLQC-30 V3.0 and Karnofsky scoring) before and after the chemotherapy; Chemotherapy was divided into two periods(the first chemotherapy period and the second one). Patients in group A accepted the scheme of therapeutic measures during the first chemotherapy and then received the plan of controlled measures during the second chemotherapy; and vice versa, patients in Group B accepted the plan of controlled measures during the first chemotherapy and then received the scheme of therapeutic measures during the second chemotherapy. The therapeutic measures were using abdominal acupuncture during routine chemotherapy, while controlled measures were receiving routine chemotherapy. Data from therapeutic measures and controlled measures were analyzed as the treatment group and control group respectively. During chemotherapy patients were affected in 5 dimensions of QOL which were the role, emotional, nausea, insomnia, loss of appetite. Abdominal acupuncture can help to improve 4 dimensions of QOL which are the emotional, fatigue, nausea, insomnia, and appetite, and have better results in Karnofsky scoring than the control group after chemotherapy. We assume under the guidance of Shenque qi distribution therapy, abdominal acupuncture therapy could help to promote healthy qi, smooth activity of qi, and keep patients under good condition and improve their QOL after chemotherapy.