机构：[1]Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China[2]Department of Clinical Laboratory, Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, China[3]Department of Clinical Laboratory, Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), 111 Dade Road, Guangzhou 510120, China大德路总院检验科大德路总院检验科广东省中医院[4]Department of Central Laboratory, Peoples Hospital of Penglai, 89 Xianhou Road, Penglai 265600, China[5]Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
To characterize the sequence variation of the gp350/220 and explore its potential association with EBV-associated tumors, the gp350/220 gene was sequenced from 41 EBV-associated gastric carcinoma (EBVaGC) and 81 nasopharyngeal carcinoma (NPC) biopsies as well as 35 throat washing (TW) samples from healthy donors. Preferential linkages between variants of the N-terminus of gp350/220 and EBNA3C variants were detected, and type A/BLLF1-a was the dominant variant in this study. The dominant variant in the C-terminal region of gp350/220 was 9P. The similar distribution of gp350/220 variants in NPC, EBVaGC and healthy donors suggest that gp350/220 variations are geographically restricted rather than tumor-specific polymorphisms.
基金：
National Natural Science Foundation of China [NSFC 30740068, NSFC30471623]; Natural Science Foundation of Shandong Province [Y2008C90]; Science and Technology of Qingdao City, China [08-2-3-7-hz, 08-2-1-4-nsh]
第一作者机构：[1]Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China
通讯作者：
推荐引用方式(GB/T 7714)：
Luo Bing,Liu Mengyang,Chao Yan,et al.Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma[J].ARCHIVES OF VIROLOGY.2012,157(2):207-216.doi:10.1007/s00705-011-1148-z.
APA：
Luo, Bing,Liu, Mengyang,Chao, Yan,Wang, Yun,Jing, Yongzheng&Sun, Zhifu.(2012).Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma.ARCHIVES OF VIROLOGY,157,(2)
MLA：
Luo, Bing,et al."Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma".ARCHIVES OF VIROLOGY 157..2(2012):207-216
