机构：[1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China大德路总院针灸科大德路总院针灸科广东省中医院[2]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China广东省中医院[3]The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China广东省中医院深圳市中医院深圳医学信息中心
Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression. The present study was conducted to explore the role of the cAMP cascade in antidepressant action of electroacupuncture (EA) treatment for chronic mild stress (CMS)-induced depression model rats. The results showed that EA improved significantly behavior symptoms in depression and dysfunction of AC-cAMP-PKA signal transduction pathway induced by CMS, which was as effective as fluoxetine. Moreover, the antidepressant effects of EA rather than Fluoxetine were completely abolished by H89, a specific PKA inhibitor. Consequently, EA has a significant antidepressant treatment in CMS-induced depression model rats, and AC-cAMP-PKA signal transduction pathway is crucial for it.
基金：
National Basic Research Program of China (973 Program) (no. 2010CB530500 and no.
2010CB530503), the National Nature Science Foundation
of China (no. 30772828), and the Foundation of Chinese
Ministry of Education (no. 20094425110005).
第一作者机构：[1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Jian-hua,Wu Zhi-feng,Sun Jian,et al.Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2012,2012:doi:10.1155/2012/932414.
APA：
Liu, Jian-hua,Wu, Zhi-feng,Sun, Jian,Jiang, Li,Jiang, Shuo&Fu, Wen-bin.(2012).Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012,
MLA：
Liu, Jian-hua,et al."Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2012.(2012)
