机构：[1]Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510006, China广东省中医院[2]College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
The interaction between drug molecules and target proteins is the basis of pharmacological action. The pharmacodynamic mechanism of Chinese medicinal plants for chronic kidney disease (CKD) was studied by molecular docking and complex network analysis. It was found that the interaction network of components-proteins of Chinese medicinal plants is different from the interaction network of components-proteins of drugs. The action mechanism of Chinese medicinal plants is different from that of drugs. We also found the interaction network of components-proteins of tonifying herbs is different from the interaction network of components-proteins of evil expelling herbs using complex network research approach. It illuminates the ancient classification theory of Chinese medicinal plants. This computational approach could identify the pivotal components of Chinese medicinal plants and their key target proteins rapidly. The results provide data for development of multi-component Chinese medicine.
基金：
National Natural Science Foundation of Guangdong Province [9151063201000050]; Foundation of Administration of Traditional Chinese Medicine of Guangdong Province [2008334]; Major Program of Science and Technique Project of Guangdong Province [2009A030100006]
第一作者机构：[1]Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510006, China
通讯作者：
通讯机构：[1]Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510006, China[2]College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
推荐引用方式(GB/T 7714)：
Zhu Wei,Qiu XiaoHui,Xu XiaoJie,et al.Computational network pharmacological research of Chinese medicinal plants for chronic kidney disease[J].SCIENCE CHINA-CHEMISTRY.2010,53(11):2337-2342.doi:10.1007/s11426-010-4082-0.
APA：
Zhu Wei,Qiu XiaoHui,Xu XiaoJie&Lu ChuanJian.(2010).Computational network pharmacological research of Chinese medicinal plants for chronic kidney disease.SCIENCE CHINA-CHEMISTRY,53,(11)
MLA：
Zhu Wei,et al."Computational network pharmacological research of Chinese medicinal plants for chronic kidney disease".SCIENCE CHINA-CHEMISTRY 53..11(2010):2337-2342
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