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CRISPR/Cas9 for cancer treatment: technology, clinical applications and challenges

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收录情况： ◇ SCIE

作者：

机构： [1]Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany [2]The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,China [3]Department of Rehabilitation, Huai’an Second People’s Hospital, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China [4]the University of Sun Yat-sen University, Guangzhou, China

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关键词： application cancer treatment challenge CRISPR/Cas9 technology

摘要：

Clustered regularly interspaced short palindromic repeats (CRISPR) is described as RNA mediated adaptive immune system defense, which is naturally found in bacteria and archaea. CRISPR-Cas9 has shown great promise for cancer treatment in cancer immunotherapy, manipulation of cancer genome and epigenome and elimination or inactivation of carcinogenic viral infections. However, many challenges remain to be addressed to increase its efficacy, including off-target effects, editing efficiency, fitness of edited cells, immune response and delivery methods. Here, we explain CRISPR-Cas classification and its general function mechanism for gene editing. Then, we summarize these preclinical CRISPR-Cas9-based therapeutic strategies against cancer. Moreover, the challenges and improvements of CRISPR-Cas9 clinical applications will be discussed. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]

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出版当年[2019]版：

大类 | 2 区生物

小类 | 2 区生物工程与应用微生物 3 区遗传学

最新[2025]版

：

大类 | 4 区生物学

小类 | 4 区生物工程与应用微生物 4 区遗传学

JCR分区：

出版当年[2018]版：

Q2 GENETICS & HEREDITY Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 GENETICS & HEREDITY

影响因子： 2.5 最新[2023版] 3.4 最新五年平均 3.133 出版当年[2018版] 3.402 出版当年五年平均 3.783 出版前一年[2017版] 2.941 出版后一年[2019版]

第一作者：

第一作者机构： [1]Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany [*1]Department of Rehabilitation, Huai’an Second People’s Hospital, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223000, China

通讯作者：

通讯机构： [1]Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany [4]the University of Sun Yat-sen University, Guangzhou, China [*1]Department of Rehabilitation, Huai’an Second People’s Hospital, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223000, China [*2]Department of Orthopedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510030, China

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CRISPR/Cas9 for cancer treatment: technology, clinical applications and challenges

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