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Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China [2]School of Medicine, Chengdu University, Chengdu 610106, China [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China

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关键词： c-Jun JNK Lung cancer Nagilactone E Programmed death ligand 1

摘要：

Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell membrane. Mechanistically, NLE increased the phosphorylation and expression of c-Jun, and promoted the localization of c-Jun in the nucleus, while silencing of c-Jun by small interfering RNA (siRNA) reduced NLE-induced PD-L1. Further study showed that NLE activated the c-Jun N-terminal kinases (JNK), the upstream of c-Jun, and its inhibitor SP600125 reversed the NLE-increased PD-L1. Moreover, NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell surface. In summary, NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-Jun axis, which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer. © 2020 China Pharmaceutical University

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区全科医学与补充医学 3 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区全科医学与补充医学 2 区药学

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出版当年[2018]版：

Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Q3 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY

影响因子： 4 最新[2023版] 3.7 最新五年平均 1.773 出版当年[2018版] 1.995 出版当年五年平均 1.991 出版前一年[2017版] 2.014 出版后一年[2019版]

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第一作者机构： [1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China

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