机构：[1]Integrative Breast Cancer Research Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[2]The Research Centre for Integrative Medicine, Discipline of Integrated Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Guangdong, China[3]Integrative Breast Cancer Research Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院
The current chapter focuses on the role of inflammasome in cancer prevention and development. Emerging evidence suggested that inflammasome is closely correlated with elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enhanced mitochondrial oxidative stress, and activation of autophagic process in cancer. Meanwhile, inflammasome component NOD-like receptors (NLRs) are also involved in carcinogenesis and closely correlated to chemoresponse and prognosis. Although several lines indicated the duplex role of inflammasome in cancer development, the phenomenon might be attributed to NLR difference, cell and tissue type, cancer stage, and specific experimental conditions. Designation of inflammasome targeting strategy has become a novel tool for cancer prevention or treatment.
基金：
This work was supported by the National Natural science Foundation of China
(81573651, 81703749 and 81703764), Guangdong Science and Technology Department
(2016A030306025), Pearl River S&T Nova Program of Guangzhou (201506010098), Combined
Scientific Project Funded by Guangdong Provincial Science and Technology Agency and Guangdong
Provincial Academy of Traditional Chinese Medicine (2014A020221047), Guangdong
Highlevel university construction project (A1-AFD018161Z1510, A1-AFD01817Z11102,
A1-AFD01817Z11101), Guangdong High-level Personnel of Special Support Program
(A1-3002-16-111-003) and The PhD Start-up Fund of Natural Science Foundation of Guangdong
Province, China (2017A030310213).
语种：
外文
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Integrative Breast Cancer Research Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhiyu Wang,Neng Wang,Yifeng Zheng,et al.Inflammasome and Cancer[J].INFLAMMASOMES: CLINICAL AND THERAPEUTIC IMPLICATIONS.2018,108:281-302.doi:10.1007/978-3-319-89390-7_12.
APA：
Zhiyu Wang,Neng Wang,Yifeng Zheng&Shengqi Wang.(2018).Inflammasome and Cancer.INFLAMMASOMES: CLINICAL AND THERAPEUTIC IMPLICATIONS,108,
MLA：
Zhiyu Wang,et al."Inflammasome and Cancer".INFLAMMASOMES: CLINICAL AND THERAPEUTIC IMPLICATIONS 108.(2018):281-302
