Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture
机构：[a]Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, Guangdong Province, China[b]Central Laboratory, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China广东省中医院
We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA.
基金：
Supported by: Research
Projects of Science and
Technology Bureau of
Foshan City, No.04080131*;
fund by the Administration
Bureau of Traditional
Chinese Medicine of
Guangdong Province, No.
1050006*; and the Natural
Science Foundation of
Guangdong Province, No.
81 52800007000001*
语种：
外文
中科院(CAS)分区：
出版当年[2010]版：
无
最新[2025]版：
大类|2 区医学
小类|2 区细胞生物学2 区神经科学
第一作者：
第一作者机构：[a]Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, Guangdong Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Tan F,Wan S,Wu H,et al.Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture[J].Neural Regeneration Research.2011,6(36):
APA：
Tan, F,Wan, S,Wu, H,Huo, Q,Wang, J...&Sun, J.(2011).Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture.Neural Regeneration Research,6,(36)
MLA：
Tan, F,et al."Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture".Neural Regeneration Research 6..36(2011)
