In view of a series of questions faced by some common automatic technologies, such as dealing with data manually and developing interface generation tool manually and so on, this paper presents a rapid development model of generating interface and accessing data based on XML documents ,and apply it in the development of medical clinical data management system. This model contains two parts: interface generation engine and data automatic access, which uses abstract factory pattern to construct, apply the polymorphic object-oriented language features and reflection skills so that it can switch quickly between various databases and application platforms. It is testified that this method can save 60 percent form designing time when comparing with manual method, thus greatly improved the system development efficiency and maintainability. © 2011 IEEE.