机构：[1]Emergency Center， The First Hospital Affiliated to Guangzhou University of Traditional Chinese,Medicine and Pharmmacologv， Guangshou 510407， China[2]Department of Clinical Phamacology, Sun Yat-sen University of Medical Sciences，Guangzhou 510089, China[3]Guangzhou Institute of Obstetrics and Gynecology，Guangzhou 510150，China
AIM: To study the inhibitory effect of ligustrazine (Lig) on growth of cultured rabbit aortic vascular smooth muscle cells (VSMC) after balloon injury. METHODS: Twenty New Zealand white rabbits were subjected to arterial injury with a balloon catheter (810 kPa for three consecutive inflations, 1 min each time). The uptake of [3H]thymidine in primary cultural VSMC incubated with rabbit serum, which obtained from the animals treated without or with Lig (40 mg · kg-1 · d-1, iv) for 21 d(7 d before and 14 d after the injury procedure) was determined. The determination was performed in direct addition of TMP to culture as well. And histological cross-sections of the blood wall were also analyzed. RESULTS: After balloon injury the intimal thickening (77 ± 23) μm and lumen diameter narrowing (877 ± 118) μm in dilated sites were increased significantly than the normal adjacent wall [(41 ± 13) μm, P < 0.01; (1033 ± 175) μm, P < 0.05, respectively]. Treatment with Lig decreased both intimal thickening (56 ± 16) μm (P < 0.05) and lumen diameter narrowing (1023 ± 157) μm (P < 0.05). Lig inhibited [3H]thymidine uptake in VSMC incubated with the serum obtained from these rabbits. Direct addition of Lig inhibited [3H] thymidine uptake in cultured VSMC in a dose-dependent manner (40-4000) μg/well. CONCLUSION: Lig shows a pronounced inhibitory effect on VSMC proliferation after balloon injury.
语种：
外文
中科院(CAS)分区：
出版当年[1998]版：
无
最新[2025]版：
大类|2 区医学
小类|1 区药学2 区化学：综合
第一作者：
第一作者机构：[1]Emergency Center， The First Hospital Affiliated to Guangzhou University of Traditional Chinese,Medicine and Pharmmacologv， Guangshou 510407， China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Song,Wang JianHua,Chen ShengLan.Inhibitory effect of ligustrazine on proliferation of rabbit vascular smooth muscle cells after arterial injury[J].Acta Pharmacologica Sinica.1999,20(10):
APA：
Li, Song,Wang, JianHua&Chen, ShengLan.(1999).Inhibitory effect of ligustrazine on proliferation of rabbit vascular smooth muscle cells after arterial injury.Acta Pharmacologica Sinica,20,(10)
MLA：
Li, Song,et al."Inhibitory effect of ligustrazine on proliferation of rabbit vascular smooth muscle cells after arterial injury".Acta Pharmacologica Sinica 20..10(1999)
