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Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway.

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收录情况： ◇ SCIE

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机构： [1]Department of Stomatology, Peopleʼs Hospital Longhua Shenzhen, Shenzhen, Guangdong, China [2]Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China [3]Transplantation Center, Third Xiangya Hospital, Central South University, Changsha, Hunan, China [4]Institute of Reproductive and Stem Cell Engineering, School of Basic Medical, Central South University, Changsha, Hunan, China [5]Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China [6]Department of Respiration, The Second Peopleʼs Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, Hunan, China

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Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two microarray datasets. LINC01116 was highly overexpressed in HNSCC tissues and was correlated to shorter overall survival and relapse-free survival duration, as analyzed by the online Gene Expression Profiling Interactive Analysis platform. LINC01116 was also overexpressed in oral squamous cell carcinoma and nasopharyngeal carcinoma tissues, and LINC01116 silencing significantly inhibited the migration and invasion capacities of both cell lines by blocking the epithelial-mesenchymal transition process. In addition, 125 coexpressing genes were identified by circlncRNAnet, and were mainly located on human autosomes and enriched in transforming growth factor-β signaling pathway. These findings indicate that LINC01116 might be a potential therapeutic target for HNSCC. © 2019 Wiley Periodicals, Inc.

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出版当年[2019]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2018]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.1 最新五年平均 3.448 出版当年[2018版] 3.342 出版当年五年平均 2.959 出版前一年[2017版] 4.237 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Stomatology, Peopleʼs Hospital Longhua Shenzhen, Shenzhen, Guangdong, China [2]Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

通讯作者：

通讯机构： [5]Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China [6]Department of Respiration, The Second Peopleʼs Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, Hunan, China [*1]Department of Stomatology, Xiangya Hospital, Central South University, 87 Xiangya St, Changsha, 410008 Hunan, China. [*2]Department of Respiration, The Second Peopleʼs Hospital of Hunan Province of Hunan University of Chinese Medicine, Changsha, 410208 Hunan, China.

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