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Apple polysaccharide could promote the growth of Bifidobacterium longum.

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机构： [a]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou 646000, Sichuan, PR China [b]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, PR China [c]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai 200437, PR China [d]Department of Pharmacy, The First Naval Force Hospital of Southern Theatre Command, Zhanjiang 524005, Guangdong, PR China [e]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China [f]Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China

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It is widely accepted that regulating microbiome could improve human health. We previously observed apple polysaccharide (AP) reversed high-fat-induced microbial dysbiosis, but the mechanism remains to be elucidated. In this study, the function of AP in vitro was evaluated in Bifidobacterium longum (B. longum) and Lactobacillus rhamnosus (L. rhamnosus). The effects of AP on the composition of fecal bacteria of normal SD rats were investigated by qPCR, TA cloning and 16S sequencing. 0.125-2% AP showed no significant effect on the growth of B. longum and L. rhamnosus. DNA concentration of fecal bacteria cultured with 1% AP was significantly higher than that of control group. qPCR revealed that the number of Bifidobacterium and Lactobacillus in fecal flora incubated by 1% AP was significantly higher than that of control group. Three strains of escherichia coli (E. coli) in fecal bacteria were screened out and analyzed. AP can be utilized by one E. coli and the metabolic products of AP could enhance the proliferation of B. longum. These data suggest that AP could promote the growth of B. longum indirectly, and provide another basis to understand the health care function of apple. Copyright © 2019 Elsevier B.V. All rights reserved.

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出版当年[2019]版：

大类 | 2 区化学

小类 | 2 区应用化学 2 区高分子科学 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

第一作者：

第一作者机构： [a]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou 646000, Sichuan, PR China [d]Department of Pharmacy, The First Naval Force Hospital of Southern Theatre Command, Zhanjiang 524005, Guangdong, PR China

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通讯作者：

通讯机构： [b]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, PR China [c]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai 200437, PR China [*1]China State Institute of Pharmaceutical Industry, Shanghai, Biological Substance Evaluation and Research Center, Shanghai 200040, PR China

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