个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter.

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Song Fan[1,2] * ; Tian Tian[3] ; Xiaobin Lv[4] ; Xinyuan Lei[1,5] ; Zhaohui Yang[2] ; Mo Liu[1] ; Faya Liang[1] ; Shunrong Li[1] ; Xiaofeng Lin[1] ; Zhaoyu Lin[1] ; Shule Xie[1] ; Bowen Li[2] ; Weixiong Chen[2,6] ; Guokai Pan[2] ; Xinyu Lin[1] ; Zhanpeng Ou[1] ; Yin Zhang[1] ; Yu Peng[1] ; Liping Xiao[1] ; Lizao Zhang[1] ; Sheng Sun[7] ; Hanqing Zhang[1] ; Sigeng Lin[8] ; Qunxing Li[1] ; Binghui Zeng[9] ; Filippos Kontos[10] ; Yi Ruan[11] ; Soldano Ferrone[10] ; Dechen Lin[1] ; Bakhos A. Tannous[12] ; Jinsong Li[1,2] ;
机构： [1]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital,Guangzhou 510120, China [2]Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Guangzhou 510120, China [3]Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, Jiangsu 211166, China [4]Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research,Center Laboratory, the Third Affiliated Hospital, Nanchang University, Nanchang 330047,China [5]State University of New Yorkat Stony Brook, Stony Brook,NY 11794, USA [6]Department of Stomatology, Longgang Distric Central Hospital,Affliated to Guangzhou University of Traditional Chinese Medicine, Shenzhen,Guangdong 518116, China [7]Massachusetts General Hospital Cancer Center,Harvard Medical School,Boston, MA 02114, USA [8]Department of Oral and Maxillofacial Surgery, Hainan General Hospital, Hainan 570300, China [9]Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou510055, China [10]Department of Surgery,Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street,Boston, MA 02114, USA [11]Department of Oral Medicine, Sun Yat-Sen Memorial Hospital of SunYat-Sen University,Guangzhou 510120, China [12]Experimental Therapeuticsand Molecular Imaging Lab,Department of Neurology,Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129,USA
出处：
DOI： 10.1016/j.isci.2020.100835
ISSN：

摘要：
Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 promoter and forms an RNA-DNA triplex structure, sequestering BRCA1 transcription factor-GABPA away from the downstream regulatory binding region. Importantly, the clinical relevance of these findings is suggested by the significant association of CISAL and BRCA1 expression levels in TSCC tumors with neoadjuvant chemosensitivity and overall survival. We propose a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites. Our study uncovers the potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (No. 81472521 to S.F.; 81402251 to J.S.L.;81502350 to X.B. Lv; 81672676 to J.S.L.; 81772890 to S.F.); Guangdong Science and Technology Development Fund (2015A030313181 to S.F.; 2016A030313352 to J.S.L.;2017A030311011 to J.S.L.); Science and Technology Program of Guangzhou (201607010108 to S.F.; 201803010060 to J.S.L.); Fundamental Research Funds for the Central Universities (16ykpy10 to S.F.);National Clinical Key Specialty Construction Project for Department of Oral and Maxillofacial Surgery to S.F. and J.S.L., The Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University(Grant KLB09001 to J.S.L.); Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology ([2013]163 to J.S.L.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
无
最新[2025]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
JCR分区：
出版当年[2018]版：
无
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital,Guangzhou 510120, China [2]Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Guangzhou 510120, China
通讯作者：
通讯机构： [1]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital,Guangzhou 510120, China [2]Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Guangzhou 510120, China
推荐引用方式(GB/T 7714)：
Song Fan,Tian Tian,Xiaobin Lv,et al.lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter.[J].ISCIENCE.2020,23(2):doi:10.1016/j.isci.2020.100835.
APA：
Song Fan,Tian Tian,Xiaobin Lv,Xinyuan Lei,Zhaohui Yang...&Jinsong Li.(2020).lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter..ISCIENCE,23,(2)
MLA：
Song Fan,et al."lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter.".ISCIENCE 23..2(2020)

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号