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Efficacy of Intermittent or Continuous Very Low-Energy Diets in Overweight and Obese Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analyses.

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机构： [1]Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China [2]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China [3]Department of Endocrinology Nephropathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China [4]Institute of Nephrology, Zhanjiang Key Laboratory of Prevention and Management of Chronic Kidney Disease, Guangdong Medical University, Zhanjiang, Guangdong 524001, China

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This study is aimed at investigating the efficacy of a very low-energy diet (VLED) in overweight and obese individuals with type 2 diabetes mellitus (T2DM). We thoroughly searched eight electronic resource databases of controlled studies concerning the efficacy and acceptability of intermittent or continuous VLEDs in patients with T2DM compared with other energy restriction interventions. Eighteen studies (11 randomized and seven nonrandomized controlled trials) with 911 participants were included. The meta-analyses showed that compared with a low-energy diet (LED) and mild energy restriction (MER), VLED is superior in the reduction of body weight (mean difference (MD) MDLED = -2.77, 95% confidence interval (CI) CILED = -4.81 to - 0.72, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, I2 = 0%) and TG level (MD = -0.25, 95%CI = -0.55 to 0.06, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, I2 = 0%) and TG level (MD = -0.25, 95%CI = -0.55 to 0.06, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39, PLED = 0.008; MDMER = -6.72, 95%CIMER = -10.05 to - 3.39. Dietary intervention through VLEDs is an effective therapy for rapid weight loss, glycemic control, and improved lipid metabolism in overweight and obese individuals with T2DM. Thus, VLEDs should be encouraged in overweight and obese individuals with T2DM who urgently need weight loss and are unsuitable or unwilling to undergo surgery. As all outcome indicators have low or extremely low quality after GRADE evaluation, further clinical trials that focus on the remission effect of VLEDs on T2DM are needed. Copyright © 2020 Yi Shan Huang et al.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 4 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢 3 区医学：研究与实验

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第一作者机构： [1]Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China

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通讯机构： [1]Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China [3]Department of Endocrinology Nephropathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China [4]Institute of Nephrology, Zhanjiang Key Laboratory of Prevention and Management of Chronic Kidney Disease, Guangdong Medical University, Zhanjiang, Guangdong 524001, China

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