机构：[1]Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China [2]Department of Gastroenterology, Zibo Central Hospital, Zibo 255000, China [3]First Affiliated Hospital, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
In the 20th century, our familiar structure of DNA was the double helix. Due to technical limitations, we do not have a good way to understand the finer structure of the genome, let alone its transcriptional regulation. Until the advent of 3C technologies, we were no longer blind to this one. Three-dimensional (3D) genomics is a new subject, which mainly studies the 3D structure and transcriptional regulation of eukaryotic genomes. Now, this field mainly has Hi-C series and CHIA-PET series technologies. Through 3D genomics, we can understand the basic structure of DNA, understand the growth and development of organisms and the occurrence of diseases, so as to promote human medical and health undertakings. The review introduces the main research techniques of 3D genomics and their characteristics, the latest development of 3D genome structure, the relationship between diseases and 3D genome structure, the applications of 3D genome in precision medicine, and the development of the 4D nucleome project.
基金：
National
Natural Science Foundation of China (81541153); Guangdong Provincial
Science and Technology Programs (2016A050503046 and
2015A050502048); Southern Science and Engineering Guangdong
Laboratory Zhanjiang (ZJW-2019-07); The Public Service Platform of
South China Sea for R&D Marine Biomedicine Resources
(GDMUK201808); and Research Project of “Excellent Innovative
Talent Support Program” of Heilongjiang University of Traditional
Chinese Medicine (2018RCD13).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区生物
小类|3 区遗传学
最新[2025]版：
大类|3 区生物学
小类|3 区遗传学
第一作者：
第一作者机构：[1]Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yingqi,Tao Tao,Du Likun,et al.Three-dimensional genome: developmental technologies and applications in precision medicine.[J].Journal of human genetics.2020,65(6):497-511.doi:10.1038/s10038-020-0737-7.
APA：
Li Yingqi,Tao Tao,Du Likun&Zhu Xiao.(2020).Three-dimensional genome: developmental technologies and applications in precision medicine..Journal of human genetics,65,(6)
MLA：
Li Yingqi,et al."Three-dimensional genome: developmental technologies and applications in precision medicine.".Journal of human genetics 65..6(2020):497-511
