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Toll signaling promotes JNK-dependent apoptosis in Drosophila.

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收录情况： ◇ SCIE

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机构： [1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China. [2]College of Traditional Chinese Medicine, North China University of Science and Technology, 21 Bohai Road, Tangshan 063210, China. [3]Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong 519000, China.

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关键词： Cell death Drosophila Toll JNK ROS

摘要：

Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient evolutionary origin, regulates embryonic dorsal-ventral patterning, axon targeting and degeneration, and innate immunity. Using Drosophila as a genetic model, we characterized the role of Toll signaling in apoptotic cell death. We found that gain of Toll signaling is able to trigger caspase-dependent cell death in development. In addition, JNK activity is required for Toll-induced cell death. Furthermore, ectopic Toll expression induces the activation of JNK pathway. Moreover, physiological activation of Toll signaling is sufficient to produce JNK-dependent cell death. Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production. As Toll pathway has been evolutionarily conserved from Drosophila to human, this study may shed light on the mechanism of mammalian Toll-like receptors (TLRs) signaling in apoptotic cell death. © The Author(s) 2020.

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出版当年[2019]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学

JCR分区：

出版当年[2018]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 2.8 最新[2023版] 3.1 最新五年平均 4.056 出版当年[2018版] 3.571 出版当年五年平均 4.684 出版前一年[2017版] 3.667 出版后一年[2019版]

第一作者：

第一作者机构： [1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China.

共同第一作者：

通讯作者：

通讯机构： [1]Institute of Intervention Vessel, Shanghai 10th People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China. [3]Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong 519000, China.

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Toll signaling promotes JNK-dependent apoptosis in Drosophila.

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