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Burkholderia pseudomallei was Identified in a Melioidosis Aneurysm using Polymerase Chain Reaction Targeting 23S rRNA.

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机构： [1]The Infective Disease Department and Tropical Medicine Research Unit, Affiliated Hainan Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China. [2]Acupuncture and Massage Institute, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, People’s Republic of China.

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Melioidosis abdominal aortic aneurysm and splenic abscesses lead to poor prognosis and high mortality rate as high as 50% due to delayed/missed diagnosis. We describe an attempt to identify Burkholderia pseudomallei immediately, which was confirmed by polymerase chain reaction (PCR) and gene sequence analysis of 23S rRNA gene. PCR is not only an unambiguous identification of B. pseudomallei but also a rapid detection because B. pseudomallei may not be readily isolated. For patients of melioidosis abdominal aortic aneurysm with spleen abscess, prolonged antibiotic therapy, splenectomy and artificial vessel replacement provided an excellent result in our study. The progression, roentgenographic findings and histopathology character of melioidosis are similar to those of tuberculosis disease. PCR is useful to differentiate B. pseudomallei from Mycobacterium tuberculosis. Copyright © 2020 Elsevier Inc. All rights reserved.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区外周血管病 4 区外科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区外周血管病 4 区外科

第一作者：

第一作者机构： [1]The Infective Disease Department and Tropical Medicine Research Unit, Affiliated Hainan Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China. [*1]The Infective Disease Department and Tropical Medicine Research Unit, Affiliated Hainan Hospital of Hainan Medical University, No. 57 Xiuhua Road, Haikou 570311, Hainan Province, People’s Republic of China

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通讯机构： [1]The Infective Disease Department and Tropical Medicine Research Unit, Affiliated Hainan Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China. [*1]The Infective Disease Department and Tropical Medicine Research Unit, Affiliated Hainan Hospital of Hainan Medical University, No. 57 Xiuhua Road, Haikou 570311, Hainan Province, People’s Republic of China

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