个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Tan Yang[1] * ; Li Yuyan[2] * ; Zhou Feng[1] ; Guo Jinming[1] ; Wang Tao[1] ; Shi Yuhe[1] ; Yang Yantao[1,3,*3] ; Lu Jiandong[2,*2] ; Pei Gang[1,3,*1] ;
机构： [1]Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China [2]Shenzhen Traditional Chinese Medicine Hospital, No. 1 Fuhua Road, Shenzhen, Guangdong, 518033, PR China [3]Hunan Provincial Engineering Technology Center of Standardization and Function of Chinese Herbal Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China
出处：
DOI： 10.1016/j.jphs.2020.04.007
ISSN：

摘要：
yeyachun and danshen exist as Chinese patent medicine, Xuemai Tong, and are clearly effective at alleviating liver fibrosis (LF). Previous studies have indicated that triterpenoids from yeyachun (EFT), and phenolic acids from danshen (SMP) are effective in the treatment of LF. The regulation of intestinal flora is an effective method for treating LF. The aim of this study was to investigate the effect of a mixture of EFT and SMP on carbon tetrachloride (CCl4) induced LF. Our results showed the mixture significantly decreased liver damage and fibrosis index, and maintained liver tissue composition, compared to the model group. Moreover, the imbalance of symptoms of intestinal flora was improved. The mixture also caused changes to metabolites of gut flora. Furthermore, the expression of CD68 in liver tissues from the treated groups was significantly decreased when compared to the model group. However, no significant difference was observed from microstructure of gut tissues and LPS concentrations in the serum between mixture treated mice and model mice. This study suggests that the mixture of EFT and SMP had a significant effect on CCl4 induced LF, and the mechanism of this action, at least in part, involved the regulation of intestinal flora and their metabolites. Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 3 区 药学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 药学
JCR分区：
出版当年[2018]版：
Q3 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q2 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China [2]Shenzhen Traditional Chinese Medicine Hospital, No. 1 Fuhua Road, Shenzhen, Guangdong, 518033, PR China [3]Hunan Provincial Engineering Technology Center of Standardization and Function of Chinese Herbal Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China [*1]Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China. [*2]Shenzhen Traditional Chinese Medicine Hospital, No. 1 Fuhua Road, Shenzhen, Guangdong, 518033, PR China [*3]Pharmacy of College, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan, 410208, PR China.
推荐引用方式(GB/T 7714)：
Tan Yang,Li Yuyan,Zhou Feng,et al.Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.[J].JOURNAL OF PHARMACOLOGICAL SCIENCES.2020,143(3):165-175.doi:10.1016/j.jphs.2020.04.007.
APA：
Tan Yang,Li Yuyan,Zhou Feng,Guo Jinming,Wang Tao...&Pei Gang.(2020).Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora..JOURNAL OF PHARMACOLOGICAL SCIENCES,143,(3)
MLA：
Tan Yang,et al."Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.".JOURNAL OF PHARMACOLOGICAL SCIENCES 143..3(2020):165-175

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号