机构：[1]Shanghai Institute of Medical Imaging, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China[2]Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China[3]Department of Medical Imaging, the third Affiliated Hospital, orthopedic Hospital of Guangdong province, Southern Medical University, Guangdong 510000, China[4]School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China[5]Radiology Department, Huashan Hospital, Fudan University, Shanghai, 200040, China[6]College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China
Photodynamic therapy (PDT) has been demonstrated to be a promising strategy for the treatment of cancer, while its therapeutic efficacy is often compromised due to excessive concentrations of glutathione (GSH) as a reactive oxygen species (ROS) scavenger in cancer cells. Herein, we report the development of near-infrared (NIR) photothermal liposomal nanoantagonists (PLNAs) for amplified PDT through through the reduction of intracellular GSH biosynthesis. Such PLNAs were constructed via encapsulating a photosensitizer, indocyanine green (ICG) and a GSH synthesis antagonist, l-buthionine sulfoximine (BSO) into a thermal responsive liposome. Under NIR laser irradiation at 808 nm, PLNAs generate mild heat via a ICG-mediated photothermal conversion effect, which leads to the destruction of thermal responsive liposomes for a controlled release of BSO in a tumor microenvironment, ultimately reducing GSH levels. This amplifies intracellular oxidative stresses and thus synergizes with PDT to afford an enhanced therapeutic efficacy. Both in vitro and in vivo data verify that PLNA-mediated phototherapy has an at least 2-fold higher efficacy in killing cancer cells and inhibiting tumor growth compared to sole PDT. This study thus demonstrates a NIR photothermal drug delivery nanosystem for amplified photomedicine.
基金：
National Natural Science
Foundation of China (Grant No. 51602334); Shanghai Natural
Science Foundation (Grant No. 18ZR1405700); Project
Supported by Shanghai Municipal Science and Technology
Major Project (No. 2018SHZDZX01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区工程技术
小类|2 区材料科学：生物材料
最新[2025]版：
大类|3 区材料科学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]Shanghai Institute of Medical Imaging, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Haitao,Feng Meixia,Chen Siyu,et al.Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy.[J].Journal of materials chemistry. B.2020,8(32):7149-7159.doi:10.1039/d0tb01437k.
APA：
Sun Haitao,Feng Meixia,Chen Siyu,Wang Ruizhi,Luo Yu...&Wang Xiaolin.(2020).Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy..Journal of materials chemistry. B,8,(32)
MLA：
Sun Haitao,et al."Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy.".Journal of materials chemistry. B 8..32(2020):7149-7159
