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Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-κB signaling pathways.

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机构： [1]Department of Orthopaedics, Affiliated Foshan Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China. [2]The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China. [3]National Key Discipline and Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [4]School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia. [5]Orthopedic Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [6]Department of Rheumatology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. [7]Department of Radiography, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong, China.

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Identification of natural compounds that inhibit osteoclastogenesis will facilitate the development of antiresorptive treatment of osteolytic bone diseases. Asiaticoside is a triterpenoid derivative isolated from Centella asiatica, which exhibits varying biological effects like angiogenesis, anti-inflammation, wound healing, and osteogenic differentiation. However, its role in osteoclastogenesis remains unknown. Here, we show that Asiaticoside can suppress RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner. Asiaticoside attenuated the expression of osteoclast marker genes including Ctsk, Atp6v0d2, Nfatc1, Acp5, and Dc-stamp. Furthermore, Asiaticoside inhibited RANKL-mediated NF-κB and NFATc1 activities, and RANKL-induced calcium oscillation. Collectively, this study demonstrates that Asiaticoside inhibited osteoclast formation and function through attenuating RANKL-induced key signaling pathways, which may indicate that Asiaticoside is a potential antiresorptive agent against osteoclast-related osteolytic bone diseases. © 2018 Wiley Periodicals, Inc.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区细胞生物学 3 区生理学

第一作者：

第一作者机构： [1]Department of Orthopaedics, Affiliated Foshan Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China. [2]The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China.

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通讯作者：

通讯机构： [2]The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China. [3]National Key Discipline and Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [4]School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia. [7]Department of Radiography, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong, China. [*1]Department of Radiography, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong, China [*2]Department of Orthopaedics, Affiliated Foshan Hospital, Guangzhou University of Traditional Chinese Medicine, 6 Qinren Road, Foshan, Guangdong, China [*3]School of Biomedical Sciences, The University of Western Australia M508, 35 Stirling Hwy, Perth, WA 6009, Australia

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