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PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE-2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway.

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机构: [1]Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. [2]School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China. [3]Department of Gastroenterology, People's Hospital of Qingyuan, Guangdong, China. [4]Department of Stomatology, Guangzhou Development District Hospital, Guangzhou, China. [5]Translation Research Institute, Jinan University, Guangzhou, China. [6]Institute of Traditional Chinese Medicine & atural Products, College of Pharmacy, Jinan University, Guangzhou, China. [7]Department of Biochemistry, Basic Medical College, Jinan University, Guangzhou, China.
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Paris polyphylla var. yunnanensis, named Chong Lou, is considered an antitumor substance. In this study, we investigated the effect of PP-22, a monomer purified from P. polyphylla var. yunnanensis, on the nasopharyngeal carcinoma cell line CNE-2 in vitro. The results showed that PP-22 could inhibit the proliferation of CNE-2 cells via the induction of apoptosis, with evidence of the characteristic morphological changes in the apoptosis in the nucleus and an increase in Annexin V-positive cells. In addition, we found that PP-22 could activate the p38 mitogen-activated protein kinase (MAPK) pathway and that this activation was reversed by SB203580, a specific inhibitor of the p38 MAPK pathway. In contrast, PP-22 promoted apoptosis via an intrinsic pathway, including the endoplasmic reticulum stress pathway, in a caspase-dependent manner. A further study showed that PP-22 also induced apoptosis by downregulating the signal transducers and activators of transcription 3 (STAT3) pathway, and the inhibitory effect was also confirmed by STAT3 small interfering RNA. In addition, PP-22 could promote autophagy by inhibiting the extracellular regulated protein kinases (ERK) pathway. And autophagy plays a protective role against apoptosis. Together, these data show that PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma CNE-2 cell line. © 2018 Wiley Periodicals, Inc.

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出版当年[2018]版:
大类 | 2 区 生物
小类 | 2 区 生理学 3 区 细胞生物学
最新[2025]版:
大类 | 3 区 生物学
小类 | 3 区 细胞生物学 3 区 生理学
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第一作者机构: [1]Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. [2]School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China. [3]Department of Gastroenterology, People's Hospital of Qingyuan, Guangdong, China.
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通讯机构: [1]Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. [7]Department of Biochemistry, Basic Medical College, Jinan University, Guangzhou, China. [*1]Department of Biochemistry, Medical College, Jinan University, Guangzhou 510630, China [*2]Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510000, China.
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