详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Pediatric Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China [2]School of Chinese Medicine, Faculty ofMedicine, The Chinese University of Hong Kong, Hong Kong 999077, China [3]Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou450052, Henan, China [4]Department of Pediatric Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China [5]Department of Hematology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China [6]Department of Pediatric Surgery, GuangzhouInstitute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China

出处：

DOI：

ISSN：

摘要：

Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorphism is a candidate variant for Wilms tumor risk. The aim of the study was to determine whether TP53 rs1042522 C>G polymorphism is responsible for the risk of Wilms tumor in Chinese children. All subjects (355 cases and 1070 controls) from four centers of China were genotyped for rs1042522 C>G polymorphism. The effect of rs1042522 C>G polymorphism on Wilms tumor prevalence was analyzed using logistic regression models. We failed to detect a significant relationship between rs1042522 C>G polymorphism and Wilms tumor risk. Further stratification analysis also could not detect a significant relationship. We conclude that TP53 rs1042522 C>G polymorphism might not have enough impact on the risk of Wilms tumor. More validation study with larger sample size will be required to better define the role of TP53 rs1042522 C>G polymorphism in Wilms tumor risk. © 2019 The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Department of Pediatric Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：