机构：[1]School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.[2]Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, Guangzhou Key Laboratory of Tumor Immunology Research, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.[3]Department of Traditional Chinese Medicine, People’s Hospital of Qinghai Province, Xining 810007, China.[4]Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.[5]Department of Biochemistry and Molecular Biology, Guangdong Provincial Key Laboratory of Biochip, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.
Echinococcosis is a zoonotic infection caused by cestode species of the genus Echinococcus, with limited treatment options. It is urgent to develop new anti-hydatid agent. In this paper, we reported anacardic acid (AA), a natural product isolated from the Brazilian cashew-nut shell liquid, which presented a high activity against metacestodes of Echinococcus multilocularis (E. multilocularis) and Echinococcus granulosus sensu stricto (E. granulosus s.s.) in vitro and in vivo. AA exerted a better efficacy on E. granulosus s.s. protoscoleces and E. multilocularis metacestodes than that of albendazole (ABZ) and dihydroartemisinin (DHA) in vitro, and an inhibition on the growth of Echinococcus metacestode as effective as ABZ in vivo. Moreover, we also found that one of the mechanisms of AA against Echinococcus could be the suppression of angiogenesis on/in the metacestode mass through inhibiting vascular endothelial growth factor (VEGF)-induced signalling pathways. This work finds that AA is a new promising potential candidate drug for echinococcosis treatment.
基金：
This research was supported by National Natural Science Foundation of China
(Nos. 81701836, 81171632 and 81702413), the Fundamental Research Funds
for the Central Universities (No. lzujbky-2014-m02), 2017 High Level University
Program-Research Foundation for Advanced Talents (Nos. C1034214 and
C1034220), and Scientific Research Starting Foundation of Southern Medical
University (No. C1034409), the Guangdong Natural Science Foundation (No.
C1051164). We are grateful to Rufida Ali from Sudan for the polish of the
manuscript.
语种：
外文
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出版当年[2018]版：
大类|2 区农林科学
小类|1 区兽医学
最新[2025]版：
大类|2 区农林科学
小类|1 区兽医学
第一作者：
第一作者机构：[1]School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.[2]Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, Guangzhou Key Laboratory of Tumor Immunology Research, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yuan Miaomiao,Song Xiaoxia,Lv Wei,et al.Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis.[J].Veterinary research.2019,50(1):3.doi:10.1186/s13567-019-0621-7.
APA：
Yuan Miaomiao,Song Xiaoxia,Lv Wei,Xin Qi,Wang Li...&Jing Tao.(2019).Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis..Veterinary research,50,(1)
MLA：
Yuan Miaomiao,et al."Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis.".Veterinary research 50..1(2019):3
农林科学