机构：[1]Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory,The Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330008[2]State Key Laboratory ofOncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center,Guangzhou, Guangdong 510060[3]Respiratory Department, Nanchang Hospital of Integrative Traditional Chinese andWestern Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330008, P.R. China[4]College of Arts and Sciences, Cornell University, Ithaca, NY 14850, USA[5]Department of Radiation Oncology,The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541000[6]Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China
Mortality factor 4-like 1 (MORF4L1) is a member of a subgroup of histone acetyltransferases and belongs to the mortality factor on chromosome 4 (MORF4) class of proteins. However, the role of MORF4L1 in cancers is largely unknown. Using reverse transcription-quantitative polymerase chain reaction and published datasets, the present study demonstrated that the expression of MORF4L1 is decreased in several cancers, including nasopharyngeal carcinoma (NPC). Additionally, the methylation rate of the promoter of MORF4L1 was identified to be significantly higher in tumour cells than in normal cells. The ectopic expression of MORF4L1 was also revealed to inhibit cell proliferation, colony formation, migration and invasion in NPC, whereas the knockdown of MORF4L1 promoted cell proliferation, colony formation, migration and invasion. Mechanistically, the present study demonstrated that MORF4L1 functions as a tumour suppressor by increasing p21 and E-cadherin levels. These findings may be useful novel targets for treating patients with NPC.
基金：
The present study was supported by National Science Foundation of China (grant no. 81660449 to YS; grant no. 81460430 to SWL; grant no. 81660452 to LZ) and Jiangxi Provincial Natural Science Foundation of China (grant no. 20161ACB21001, to YS; grant no. 20161BAB215188, to GH).
第一作者机构：[1]Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory,The Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330008
共同第一作者：
通讯作者：
通讯机构：[1]Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory,The Third Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330008[6]Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China[*1]Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory, The Third Affiliated Hospital, Nanchang University, 128 Xiangshan North Road, Nanchang, Jiangxi 330008, P.R. China[*2]Department of Radiation Oncology, Jiangxi Cancer Hospital, 519 Beijing East Road, Nanchang, Jiangxi 330029, P.R. China
推荐引用方式(GB/T 7714)：
Sang Yi,Zhang Ruhua,Sun Longhua,et al.MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E-cadherin expression in nasopharyngeal carcinoma.[J].ONCOLOGY LETTERS.2019,17(1):294-302.doi:10.3892/ol.2018.9588.
APA：
Sang Yi,Zhang Ruhua,Sun Longhua,Chen Kaddie Kwok,Li Si-Wei...&Huang Guofu.(2019).MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E-cadherin expression in nasopharyngeal carcinoma..ONCOLOGY LETTERS,17,(1)
MLA：
Sang Yi,et al."MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E-cadherin expression in nasopharyngeal carcinoma.".ONCOLOGY LETTERS 17..1(2019):294-302
