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Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.

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机构： [1]Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China [2]Department of Clinical Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China [3]College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China

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关键词： Lead Icaritin Osteoblastic differentiation Canonical wnt pathway

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Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed bone nodule formation and inhibited differentiation in MC3T3-E1 subclone 14 cells, as shown by decreased expression levels of the differentiation markers alkaline phosphatase (ALP), type 1 collagen (COL1), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2). Moreover, Pb inactivated the canonical Wnt pathway by regulating key components, such as Wnt3a, Dkk-1, pGSK3β, and β-catenin. Icaritin (ICT), a hydrolytic product of icariin from the genus Epimedium, attenuates the inhibitory effect of Pb on osteoblastic differentiation, as well as activate the canonical Wnt signal pathway. Taken together, the results suggest ICT as a potential bone protectant that may be used to prevent bone damage caused by Pb and can activate the canonical Wnt signal pathway. Copyright © 2019. Published by Elsevier B.V.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 2 区毒理学 3 区生化与分子生物学 3 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 1 区毒理学 2 区生化与分子生物学 2 区药学

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第一作者机构： [1]Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China [3]College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China

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Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.

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Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.