机构：[1]Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central SouthUniversity, 410083 Changsha, China[2]Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional ChineseMedicine, Xiangya Hospital, Central South University, 410008 Changsha, China[3]Key Laboratry of Materials Processing and Mold, Ministry of Education,Zhengzhou University, 450002 Zhengzhou, China[4]Xiangya School of Medicine, Central South University, 410013 Changsha, China[5]Yunnan Food SafetyResearch Institute, Kunming University of Science and Technology, 650500 Kunming, China[6]Department of Chemistry and Key Laboratory for Preparationand Application of Ordered Structural Materials of Guangdong Province, Shantou University, 515063 Shantou, China[7]Department of Oncology, XiangyaHospital, Central South University, 410008 Changsha, China[8]College of Integrated Traditional Chinese and Western Medicine, Hunan University of ChineseMedicine, 410208 Changsha, China[9]Southern University of Science and Technology, 518055 Shenzhen, China
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.
基金：
This work was supported by the National Natural Science Foundation of China
(Nos. 81303074, 81673719, 21473257, and 21773311), the Outstanding Youth Foundation
of Hunan Provincial Natural Science Foundation of China (No. 2019JJ30042), the
Hunan Provincial Natural Science Foundation of China (No. 2019JJ50960), and the
Special Program for Applied Research on Super Computation of NSFC-Guangdong Joint
Fund.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|1 区综合性期刊
小类|1 区综合性期刊
第一作者：
第一作者机构：[1]Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central SouthUniversity, 410083 Changsha, China
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central SouthUniversity, 410083 Changsha, China[2]Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional ChineseMedicine, Xiangya Hospital, Central South University, 410008 Changsha, China
推荐引用方式(GB/T 7714)：
Zheng Jun,Fan Rong,Wu Huiqiong,et al.Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.[J].Nature communications.2019,10(1):1604.doi:10.1038/s41467-019-09601-3.
APA：
Zheng Jun,Fan Rong,Wu Huiqiong,Yao Honghui,Yan Yujie...&Wang Yang.(2019).Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation..Nature communications,10,(1)
MLA：
Zheng Jun,et al."Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.".Nature communications 10..1(2019):1604
综合性期刊