机构：[1]Department of Hepatology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.[2]Key Laboratory for Metabolic Diseases in Chinese Medicine, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.[3]Department of Gastroenterology, Haian Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Haian, Jiangsu 226600, P.R. China.[4]Department of Psychiatry and Imageology, Central People's Hospital of Zhanjiang Affiliated to Guangdong Medical University, Zhanjiang, Guangdong 524048, P.R. China.[5]Department of Psychology and Key Laboratory of Psychological Assessment and Rehabilitation for Exceptional Children, Lingnan Normal University, Zhanjiang, Guangdong 524048, P.R. China.
Saikosaponin‑D (SSD), which is the main bioactive component in the traditional Chinese medicine Chai Hu (Bupleurum falcatum L), possesses estrogen‑like properties and is widely used in treating estrogen‑related neurological disorders. The current study aimed to investigate the protective effects of SSD on the fear memory deficit in ovariectomized (OVX) rats and the potential underlying mechanism. SSD treatment significantly prolonged freezing time in OVX rats in a manner similar to that of estradiol (E2), whereas this effect was markedly suppressed by co‑administration of ICI182780, a non‑selective estrogen receptor (ER) inhibitor. The expression of ERα in the hippocampus of OVX rats was significantly elevated by SSD; however, Erβ expression and E2 synthesis were not markedly affected by SSD treatment. Collectively, this study demonstrated that SSD‑mediated fear memory improvement in OVX rats may be attributed not to E2 levels or ERβ activity, but to ERα activation in the hippocampus.
基金：
The present study was supported by the Natural Science
Foundation of Jiangsu Province (grant nos. BK20140959
and BK20151008); the National Natural Science Foundation
of China (grant nos. 81603578 and 81503536); the Natural
Science Foundation of Universities in Jiangsu Province
(grant no. 15KJB360008); the Key Laboratory Fund of
Philosophy and Social Sciences of Universities in Guangdong
Province (Psychological Assessment and Rehabilitation for
Exceptional Children; grant no. 2017SYSYJ01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Hepatology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[5]Department of Psychology and Key Laboratory of Psychological Assessment and Rehabilitation for Exceptional Children, Lingnan Normal University, Zhanjiang, Guangdong 524048, P.R. China.[*1]Department of Psychology and Key Laboratory of Psychological Assessment and Rehabilitation for Exceptional Children, Lingnan Normal University, 29 Cunjin Road, Chikan, Zhanjiang, Guangdong 524048, P.R. China
推荐引用方式(GB/T 7714)：
Liu Lina,Yan Jing,Ge Fei,et al.Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.[J].Molecular medicine reports.2019,20(1):332-340.doi:10.3892/mmr.2019.10232.
APA：
Liu Lina,Yan Jing,Ge Fei,Xu Xiangtao,Lu Jun...&Zhang Changzheng.(2019).Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus..Molecular medicine reports,20,(1)
MLA：
Liu Lina,et al."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.".Molecular medicine reports 20..1(2019):332-340
