机构：[1]Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[3]Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Mental Health Center, Guangzhou, China[4]The Second School of Clinical Medicine, Southern Medical University, Guangdong Province, China[5]Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, China[6]Hexian Memorial Hospital, Guangzhou, China中山大学附属第二医院[7]Department of Neurology, Laibin People’s Hospital, Laibin, China[8]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
Increasing evidence indicates that immune system dysfunction affects anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti-NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and L-selectin (sL-selectin), were measured in the CSF and serum of 26 participants with anti-NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM-1, sVCAM-1 and sL-selectin were significantly elevated in the anti-NMDAR encephalitis group. sVCAM-1 levels were positively associated with modified Rankin scale score in anti-NMDAR encephalitis patients at the onset and 3-month follow-up.
基金：
This work was funded by the National
Natural Science Foundation of China
(81673950, 81760413, 81760902).
Guangdong Provincial Science and
Technology plan projects (2017A020215182,
2016A020215101). Tackling Key Problems in
Science and Technology and Trial Production
of New Products in Liuzhou (No.
2016G020213, NO2014J030407) and
Guangxi Natural Fund Project (No.
2017GXNSFBA198114).
第一作者机构：[1]Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China[8]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China[*1]Department of Neurology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong Province, Guangzhou 510515, China[*2]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, China.
推荐引用方式(GB/T 7714)：
Yuewen Ding,Chengjia Yang,Zheyi Zhou,et al.Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients.[J].ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY.2019,6(5):945-953.doi:10.1002/acn3.740.
APA：
Yuewen Ding,Chengjia Yang,Zheyi Zhou,Yu Peng,Jinyu Chen...&Honghao Wang.(2019).Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients..ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY,6,(5)
MLA：
Yuewen Ding,et al."Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients.".ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 6..5(2019):945-953
