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Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway.

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资源类型：
Pubmed体系：
作者：
Liu Sisi[1] * ; Li Guangming[1] * ; Tang Haijie[1] * ; Pan Rui[3] ; Wang Huili[1] ; Jin Fujun[1] ; Yan Xueqin[1] ; Xing Yanyan[1] ; Chen Guiling[1] ; Fu Yongmei[1] ; Dong Jun[1,2,*1] ;
机构： [1]Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China [2]GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China [3]Department of Orthopedics, The First Affiliated Hospital, Medical College of Jinan University, Guangzhou, Guangdong Province, China
出处：
DOI： 10.1016/j.neulet.2019.134386
ISSN：

关键词： Madecassoside Neuroinflammation Lipopolysaccharide Nrf2

摘要：
Neuroinflammation is a predisposing factor for several neurodegenerative diseases. The purpose of this study was to evaluate the protective effect of madecassoside (MA) in lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in rats. MA has many protective effects such as antioxidant and anti-inflammatory properties. We investigated whether MA could improve neurocognitive dysfunction caused by intracerebroventricular injection of LPS. We examined the effects and mechanisms of action of MA on LPS-induced neuroinflammation in the cortex and hippocampus. Our study revealed that MA (120 mg/kg, i.g) treatment for 14 days reduced LPS-induced neurotoxicity by reducing cognitive impairments and suppressing the production of inflammatory cytokines such as interleukin 1 beta (IL-1β), tumor necrosis factor alpha(TNF-α), and interleukin 6(IL-6) via activation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling. Furthermore, MA treatment enhanced protein levels of heme oxygenase (HO)-1 by upregulating Nrf2 in LPS-stimulated neurotoxicity. Collectively, these results suggest that MA is effective in preventing neurodegenerative diseases by improving memory functions due to its anti-inflammatory activities and activation of Keap1-Nrf2/HO-1 signaling. As such, MA may be a potential therapy for addressing memory impairment caused by neuroinflammation. Copyright © 2019 Elsevier B.V. All rights reserved.

基金：
the National Natural Science Foundation of China (81171134 and 81471235), Guangdong Provincial Natural Science Foundation of China (2014A030313360), the Program of Introducing Talents of Discipline to Universities (B14036), the Science and Technology Foundation of Guangdong (2010B030700016), and the cultivation and innovation fund of Jinan University (No.21617460).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
第一作者：
第一作者机构： [1]Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China [2]GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China [*1]Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China
推荐引用方式(GB/T 7714)：
Liu Sisi,Li Guangming,Tang Haijie,et al.Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway.[J].Neuroscience letters.2019,709:134386.doi:10.1016/j.neulet.2019.134386.
APA：
Liu Sisi,Li Guangming,Tang Haijie,Pan Rui,Wang Huili...&Dong Jun.(2019).Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway..Neuroscience letters,709,
MLA：
Liu Sisi,et al."Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway.".Neuroscience letters 709.(2019):134386

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