机构：[1]Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic,Cleveland, OH, USA[2]School of Life Sciences, Institute of ModernAquaculture Science and Engineering, Guangdong Provincial Key Laboratoryfor Healthy and Safe Aquaculture, South China Normal University,Guangzhou 510631, China[3]Department of Medical Laboratory, CentralHospital of Wuhan, Wuhan, China[4]State Key Laboratory of RespiratoryDiseases, Guangzhou Institute of Respiratory Diseases, The First AffiliatedHospital of Guangzhou Medical University, Guangzhou Medical University,Guangzhou, China[5]Department of Stomatology, the Second XiangyaHospital, Central South University, Changsha, China[6]Department ofStomatology, Xiangya Hospital, Central South University, Changsha, China[7]Department of Hematopathology, The University of Texas MD AndersonCancer Center, Houston, TX, USA[8]Institute for Brain Research andRehabilitation, South China Normal University, Guangzhou 510631, China[9]The Research Center of Basic Integrative Medicine, Guangzhou University ofChinese Medicine, Guangzhou 510006, China
Glyphosate is the most widely used herbicide in the USA and worldwide. There has been considerable debate about its carcinogenicity. Epidemiological studies suggest that multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) have a positive and statistically significant association with glyphosate exposure. As a B cell genome mutator, activation-induced cytidine deaminase (AID) is a key pathogenic player in both MM and B cell NHL.
Vk*MYC is a mouse line with sporadic MYC activation in germinal center B cells and considered as the best available MM animal model. We treated Vk*MYC mice and wild-type mice with drinking water containing 1000 mg/L of glyphosate and examined animals after 72 weeks.
Vk*MYC mice under glyphosate exposure developed progressive hematological abnormalities and plasma cell neoplasms such as splenomegaly, anemia, and high serum IgG. Moreover, glyphosate caused multiple organ dysfunction, including lytic bone lesions and renal damage in Vk*MYC mice. Glyphosate-treated wild-type mice developed benign monoclonal gammopathy with increased serum IgG, anemia, and plasma cell presence in the spleen and bone marrow. Finally, glyphosate upregulated AID in the spleen and bone marrow of both wild-type and Vk*MYC mice.
These data support glyphosate as an environmental risk factor for MM and potentially NHL and implicate a mechanism underlying the B cell-specificity of glyphosate-induced carcinogenesis observed epidemiologically.
基金：
YL is supported in part by NIH R01 grants (CA138688 and CA177810); LW is
supported by National Natural Science Foundation of China (NO. 31500326)
and Natural Science Foundation of Guangdong Province of China (NO.
2017A030313194).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|1 区医学
小类|2 区血液学2 区肿瘤学
最新[2025]版：
大类|1 区医学
小类|1 区血液学1 区肿瘤学
第一作者：
第一作者机构：[1]Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic,Cleveland, OH, USA[2]School of Life Sciences, Institute of ModernAquaculture Science and Engineering, Guangdong Provincial Key Laboratoryfor Healthy and Safe Aquaculture, South China Normal University,Guangzhou 510631, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic,Cleveland, OH, USA[8]Institute for Brain Research andRehabilitation, South China Normal University, Guangzhou 510631, China[9]The Research Center of Basic Integrative Medicine, Guangzhou University ofChinese Medicine, Guangzhou 510006, China
推荐引用方式(GB/T 7714)：
Wang Lei,Deng Qipan,Hu Hui,et al.Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.[J].Journal of hematology & oncology.2019,12(1):70.doi:10.1186/s13045-019-0767-9.
APA：
Wang Lei,Deng Qipan,Hu Hui,Liu Ming,Gong Zhaojian...&Li Yong.(2019).Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice..Journal of hematology & oncology,12,(1)
MLA：
Wang Lei,et al."Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.".Journal of hematology & oncology 12..1(2019):70
医学