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Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling.

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资源类型：
Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C

作者：
LIU Ya-Mei[1,2] * ; LI Wang-Yang[3] * ; XU Liang-Liang[4] * ; YU Li-Juan[1] ; LUO Yi-Wen[5] ; LI Xi-Can[6] ; ZHANG Xun-Chao[5] ; XIONG Yun-Pu[7] ; CHEN Hong-Tai[5] ; ZHU Jun-Lang[5] ; CHEN Chen[1,2] ; XIE Yu-Lu[6] ; CHEN Dong-Feng[8] ; WANG Bin[5] ;
机构： [1]College of Basic Medical, Guangzhou University of Chinese Medicine, Guangzhou 510006, China [2]Innovative Research & Development Lab. of TCM, Guangzhou University of Chinese Medicine, Guangzhou 510006, China [3]The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410208, China [4]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Lingnan Medical Research Center of GuangzhouUniversity of Chinese Medicine, Guangzhou 510000, China [5]Department of Traumatology, the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou510240, China [6]School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China [7]Department of Orthopaedics, Guangzhou Orthopedic hospital, Guangzhou 510030, China [8]Department of Anatomy, The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine,Guangzhou 510006, China
出处：
DOI： 10.1016/S1875-5364(19)30072-X
ISSN：

关键词： Catharmus tinctorius Volatile oil MSC Migration ROCK2/MLC signaling

摘要：
MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further exploration of the underlying molecular mechanism participating in the pro-migratory ability may provide a novel strategy to improve MSC transplantation efficacy. This study indicated that CTVO promotes MSC migration through enhancing ROCK2 mRNA and protein expressions. MSC migration induced by CTVO was blunted by ROCK2 inhibitor, which also decreased myosin light chain (MLC) phosphorylation. Meanwhile, the siRNA for ROCK2 inhibited the effect of CTVO on MSC migration ability and attenuated MLC phosphorylation, suggesting that CTVO may promote BMSC migration via the ROCK2/MLC signaling. Taken together, this study indicates that C. tinctorius volatile oil could enhance MSC migration via ROCK2/MLC signaling in vitro. C. tinctorius volatile oil-targeted therapy could be a beneficial strategy to improve the therapeutic potential of cell transplantation for bone diseases in regenerative medicine. Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

基金：
National Nature Science Foundation of China (Nos. 81503593, 81273783, and 81473699), Guangdong Science and Technology Department (No. 2014A020221055) and the Natural Science Foundation of Guangdong Province (Nos. 2016A030313649 and 2017A030313729).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 3 区 全科医学与补充医学 4 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 全科医学与补充医学 2 区 药学
第一作者：
第一作者机构： [1]College of Basic Medical, Guangzhou University of Chinese Medicine, Guangzhou 510006, China [2]Innovative Research & Development Lab. of TCM, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
LIU Ya-Mei,LI Wang-Yang,XU Liang-Liang,et al.Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling.[J].Chinese Journal of Natural Medicines.2019,17(7):506-516.doi:10.1016/S1875-5364(19)30072-X.
APA：
LIU Ya-Mei,LI Wang-Yang,XU Liang-Liang,YU Li-Juan,LUO Yi-Wen...&WANG Bin.(2019).Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling..Chinese Journal of Natural Medicines,17,(7)
MLA：
LIU Ya-Mei,et al."Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling.".Chinese Journal of Natural Medicines 17..7(2019):506-516

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