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Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathway.

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收录情况： ◇ SCIE

作者：
Zhou Houming[1] * ; Chen Shuqing[1] * ; Yang Yubin[1] ; Yang Chaojie[1] ; Chen Danping[3] ; Yao Zhenrong[2] ; Sun Baoguo[1,*1] ;
机构： [1]Department of Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University [2]Department of Laboratory, The First Affiliated Hospital of Sun Yat-Sen University [3]Department of Neurology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China
出处：
DOI： 10.1097/CAD.0000000000000796
ISSN：

关键词： adriamycin matrine osteosarcoma signal transducer and activator of transcription 3

摘要：
Matrine and adriamycin have been extensively considered to be effective in anticancer therapies. However, the role of matrine in the antitumor activity of adriamycin against human osteosarcoma (OS) remains elusive. The aim of this study was to investigate the effect of matrine in OS chemotherapy of adriamycin. In the study, we found that matrine promoted the inhibitory effect of adriamycin against OS cell proliferation and growth. Wound healing and transwell assays showed that the inhibitory effect of adriamycin against migration and invasion of OS cells was significantly enhanced by matrine. For the underlying mechanism investigation, we showed that adriamycin reduced the protein level of PCNA, MMP-9, phosphorylated STAT3, and survivin, which was further intensified by the application of matrine. These results show that matrine could promote the therapeutic efficacy of adriamycin against human OS.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 药学
JCR分区：
出版当年[2017]版：
Q3 PHARMACOLOGY & PHARMACY Q4 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY Q3 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Department of Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University
共同第一作者：
通讯作者：
通讯机构： [1]Department of Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University [*1]Department of Chinese Medicine, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Second Road, Yuexiu District, Guangzhou 510080, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhou Houming,Chen Shuqing,Yang Yubin,et al.Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathway.[J].ANTI-CANCER DRUGS.2019,30(10):1006-1012.doi:10.1097/CAD.0000000000000796.
APA：
Zhou Houming,Chen Shuqing,Yang Yubin,Yang Chaojie,Chen Danping...&Sun Baoguo.(2019).Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathway..ANTI-CANCER DRUGS,30,(10)
MLA：
Zhou Houming,et al."Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathway.".ANTI-CANCER DRUGS 30..10(2019):1006-1012

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