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HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.

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资源类型：
Pubmed体系：
作者：
Jiang Honghong[1,2,3] * ; Fu Qiaofen[1,2] * ; Song Xin[1,2] * ; Ge Chunlei[2] ; Li Ruilei[2] ; Li Zhen[2] ; Zeng Baozhen[2] ; Li Chunyan[2] ; Wang Ying[2] ; Xue Yuanbo[2] ; Luo Rongcheng[1,*1] ; Fang Weiyi[1,*1] ;
机构： [1]Cancer Centre, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou,Guangdong 510315 [2]Department of Cancer Biotherapy Centre, Third Affiliated Hospital of Kunming Medical University(Tumour Hospital of Yunnan Province), Kunming, Yunnan 510118 [3]Department of Ultrasound,Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China
出处：
DOI： 10.3892/ol.2019.10812
ISSN：

关键词： hepatoma‑derived growth factor protein kinase Cα lung adenocarcinoma

摘要：
Lung adenocarcinoma is the most common histologic subtype of lung cancer. The aim of the present study was to assess the expression of hepatoma-derived growth factor (HDGF) and protein kinase Cα (PRKCA) in lung adenocarcinoma (LADC), and to determine the association between the combined expression of these two proteins and clinicopathological characteristics of patients with LADC. The expression of HDGF and PRKCA mRNA was assessed by GEO database analysis, and HDGF and PRKCA protein levels were examined by immunohistochemistry using a tissue microarray. High HDGF and PRKCA expression was observed in LADC tissue compared to normal samples, and increased HDGF and PRKCA expression was associated with AJCC clinical stage, tumor classification, node classification, and lymph node metastasis. GEO database analysis revealed no significant differences between HDGF mRNA and PRKCA mRNA in LADC tissue. However, high PRKCA protein expression was associated with high HDGF protein expression, and patients with high HDGF and PRKCA expression exhibited poorer overall survival rates than patients with low expression levels of the two proteins. The results of the present study suggest that upregulation of both HDGF and PRKCA may be an unfavourable factor for lung adenocarcinoma progression. Copyright © 2019, Spandidos Publications.

基金：
the National Natural Science Foundation of China (grant nos. 81702295, 81660389 and 81602029), the China Postdoctoral Science Foundation (grant no. 2017M613008), the Yunnan Province Applied Foundation Project (grant nos. 2017FB127 and 2017FB126), the Yunnan Province‑Kunming Medical University Joint Foundation for Applied Basic Research (grant no. 2015FB074) and the Integrative Therapy Innovation Team for Yunnan Regional Cancer (grant no. 2017HC006).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
第一作者：
第一作者机构： [1]Cancer Centre, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou,Guangdong 510315 [2]Department of Cancer Biotherapy Centre, Third Affiliated Hospital of Kunming Medical University(Tumour Hospital of Yunnan Province), Kunming, Yunnan 510118 [3]Department of Ultrasound,Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China
共同第一作者：
通讯作者：
通讯机构： [1]Cancer Centre, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou,Guangdong 510315 [*1]Cancer Centre, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13 ShiLiuGang Road, Guangzhou, Guangdong 510315, P.R. China
推荐引用方式(GB/T 7714)：
Jiang Honghong,Fu Qiaofen,Song Xin,et al.HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.[J].Oncology letters.2019,18(5):4936-4946.doi:10.3892/ol.2019.10812.
APA：
Jiang Honghong,Fu Qiaofen,Song Xin,Ge Chunlei,Li Ruilei...&Fang Weiyi.(2019).HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma..Oncology letters,18,(5)
MLA：
Jiang Honghong,et al."HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.".Oncology letters 18..5(2019):4936-4946

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