A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis.
机构：[1]Third-Grade Pharmacological Laboratory on Chinese MedicineApproved by State Administration of Traditional Chinese Medicine,Medical College of China Three Gorges University,Yichang, Hubei 443002, China[2]Shenzhen Institute of Geriatrics, Shenzhen, Guangdong 518020,China[3]Department of Rheumatology, Nanfang Hospital, Southern MedicalUniversity, Guangzhou, Guangdong 510515, China[4]Department of Traditional Chinese Internal Medicine, School ofTraditional Chinese Medicine, Southern Medical University,Guangzhou, Guangdong 510515, China[5]Department of Orthopedic Surgery, Hunan Provincial Hospital ofTraditional Chinese Medicine, Zhuzhou, Hunan 412008, China
To assess the efficacy and safety of the combination of total glucoside of peony (TGP) and methotrexate (MTX) for the treatment of rheumatoid arthritis (RA). Randomized controlled trial (RCT) data on the traditional Chinese active component TGP combined with MTX vs. MTX alone for the treatment of RA was collected by searching the Pubmed, Embase, Cochrane Library, CNKI, VIP Journals database, and Wanfang database up to February 2017. Study selection, data extraction, data synthesis, and data analyses were performed according to the Cochrane standards. A total of eight RCTs involving 522 participants were included in this meta-analysis. Compared with MTX alone, the use of TGP combined with MTX exhibited better therapeutic effects for the treatment of RA (P = 0.004). In addition, TGP combined with MTX caused a more significant decrease in erythrocyte sedimentation rate (ESR) (P < 0.0001) and swollen joint count (SJC) (P < 0.00001). However, no significant differences were found in C-reactive protein (CRP) (P = 0.19), duration of morning stiffness (DMS) (P = 0.32), or tender joint count (TJC) (P = 0.23) between the two groups. In addition, adverse events were more frequently reported in the MTX monotherapy group than in the TGP and MTX combination group (P = 0.0007). Our study demonstrates that TGP combined with MTX is more effective than MTX alone for the treatment of RA. Nevertheless, the adverse effects of the combination of TGP and MTX need to be further assessed. Due to the poor methodological quality of included trials, well-designed, multi-center, and large-scale RCTs are necessary to draw a more definitive conclusion.
基金：
This project was supported by grants from the
Guangdong Provincial Natural Science Foundation (2015A030310067),
Guangdong Science and Technology Program (2016A020226001),
a n d Sh e n z h e n Te c h n o l o g y I n n o v a t i o n Fo u n d a t i o n
(JCYJ20150401171352927).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区风湿病学
最新[2025]版：
大类|3 区医学
小类|4 区风湿病学
第一作者：
第一作者机构：[1]Third-Grade Pharmacological Laboratory on Chinese MedicineApproved by State Administration of Traditional Chinese Medicine,Medical College of China Three Gorges University,Yichang, Hubei 443002, China[2]Shenzhen Institute of Geriatrics, Shenzhen, Guangdong 518020,China
通讯作者：
通讯机构：[3]Department of Rheumatology, Nanfang Hospital, Southern MedicalUniversity, Guangzhou, Guangdong 510515, China[4]Department of Traditional Chinese Internal Medicine, School ofTraditional Chinese Medicine, Southern Medical University,Guangzhou, Guangdong 510515, China
推荐引用方式(GB/T 7714)：
Feng Zhi-Tao,Xu Juan,He Guo-Chao,et al.A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis.[J].Clinical rheumatology.2018,37(1):35-42.doi:10.1007/s10067-017-3770-y.
APA：
Feng Zhi-Tao,Xu Juan,He Guo-Chao,Cai San-Jin,Li Juan&Mei Zhi-Gang.(2018).A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis..Clinical rheumatology,37,(1)
MLA：
Feng Zhi-Tao,et al."A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis.".Clinical rheumatology 37..1(2018):35-42
