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Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units.

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机构: [1]Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China [2]Department of Cardiology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, Zhejiang, China [3]Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong, China
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关键词: Metal-organic framework Anti-myocarditis In vivo

摘要:
A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. The results showed that compound 1 can improve hemodynamic parameters of, and it may be a good therapeutic option for heart failure in the future.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 生物学 4 区 医学:研究与实验
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 生物学 4 区 医学:研究与实验
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出版当年[2016]版:
Q2 BIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q3 BIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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