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Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-κB pathway.

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机构： [1]Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, 510080 Guangzhou, Guangdong, PR China [2]Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 330006 Nanchang, Jiangxi, PR China

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关键词： INSR IGF1R Tumorigenesis Metastasis NF-κB pathway C-myc Tongue squamous cell carcinoma

摘要：

The insulin receptor (INSR) and insulin-like growth factor 1 receptor (IGF1R) have been reported to be involved in the tumorigenesis and metastasis of various malignancies. The aim of our study was to investigate and compare the effects of INSR and IGF1R on the tumorigenesis and metastasis of tongue squamous cell carcinoma (TSCC) and explore the possible mechanism(s) involved. We found that INSR had the same up-regulated expression pattern as IGF1R in TSCC tissues. INSR and IGF1R up-regulation were correlated with each other and associated with lymph node metastasis and poor prognosis. Functional studies established that knocking down either INSR or IGF1R dramatically impeded TSCC cell proliferation, migration, and invasion in vitro and tumorigenesis and tumor metastasis in vivo, whereas ectopic overexpression of INSR or IGF1R enhanced these activities. Both INSR and IGF1R directly targeted p65 and activated the NF-κB pathway; furthermore, C-myc was observed to directly bind to the INSR and IGF1R promoters and up-regulates INSR and IGF1R expression in TSCC. Thus, our current data demonstrate that both INSR and IGF1R are directly targeted by C-myc and exert similar effects to promote the tumorigenesis and metastasis of TSCC through the NF-κB pathway. Therefore, INSR and IGF1R may be therapeutic target genes and potential prognostic factors for TSCC. Copyright © 2018 Elsevier B.V. All rights reserved.

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出版当年[2017]版：

大类 | 2 区生物

小类 | 2 区生化与分子生物学 2 区生物物理

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生物物理 3 区生化与分子生物学

JCR分区：

出版当年[2016]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 BIOPHYSICS

最新[2023]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.2 最新[2023版] 5.5 最新五年平均 5.476 出版当年[2016版] 5.725 出版当年五年平均 5.158 出版前一年[2015版] 5.108 出版后一年[2017版]

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第一作者机构： [1]Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, 510080 Guangzhou, Guangdong, PR China

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