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Second primary squamous cell carcinoma in patients with nasopharyngeal carcinoma after radiotherapy-Predictors and prognostic factors.

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收录情况： ◇ SCIE

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机构： [1]Department of Otolaryngology, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, 510405 Guangdong, People’s Republic of China [2]Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, 510060 Guangdong, People’s Republic of China [3]Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060 Guangdong, People’s Republic of China

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We investigated risk and prognostic factors for second primary squamous cell carcinoma (SCC) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy (RT). A total of 49 021 patients with NPC were treated at Sun Yat-Sen Cancer Center between January 1970 and December 2009. The incidence and management of second primary SCCs were analyzed. A total of 142 patients (0.29%) developed second primary SCC, with 78.2% in the upper aerodigestive tract. Older age, smoking, and chemotherapy were associated with an increased rate of second primary SCC. The 3, 5, and 10-year overall survival (OS) rates for second primary SCC were 47.18%, 31.69%, and 11.97%, respectively. Advanced age, family history of cancer, and treatment modality were independent prognostic factors for survival. Second primary tumors rarely develop in patients with NPC treated with RT, but when this occurs, second primary SCC comprises a majority of these. Intensity-modulated RT may shorten the latency to second primary SCC. Surgery as the first-line treatment may improve survival and prognosis. © 2018 Wiley Periodicals, Inc.

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出版当年[2017]版：

大类 | 3 区

医学

小类 | 1 区耳鼻喉科学 3 区外科

最新[2025]版：

大类 | 3 区医学

小类 | 2 区耳鼻喉科学 3 区外科

JCR分区：

出版当年[2016]版：

Q1 OTORHINOLARYNGOLOGY Q1 SURGERY

最新[2023]版：

Q1 OTORHINOLARYNGOLOGY Q1 SURGERY

影响因子： 2.4 最新[2023版] 2.8 最新五年平均 3.376 出版当年[2016版] 3.19 出版当年五年平均 2.76 出版前一年[2015版] 2.471 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Otolaryngology, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, 510405 Guangdong, People’s Republic of China

通讯作者：

通讯机构： [2]Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, 510060 Guangdong, People’s Republic of China [3]Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060 Guangdong, People’s Republic of China [*1]Department of Head and Neck Surgery, Sun Yat-sen University, Sun Yat-sen Cancer Center, Guangzhou, China.

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