机构：[1]Department of Orthopaedics and Traumatology, People's Hospital of Bao'an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao'an District, Shenzhen, China.南方医科大学深圳医院深圳市宝安区人民医院深圳市康宁医院深圳医学信息中心[2]Department of Orthopaedics and Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.[3]Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Baptist University Road, Kowloon Tong, Hong Kong, China.
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173-178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.
基金：
The work was partially supported by grants from Research Grants Council of
the Hong Kong Special Administrative Region, China (Project No. 14119115,
14160917, 9054014 N_CityU102/15, T13-402/17-N); National Natural Science
Foundation of China (81371946, 81430049 and 81772322); Hong Kong Innovation
Technology Commission Funds (ITS/UIM-305) and grants from the Shenzhen
Science and Technology Innovation Council of China (JCYJ20150630165236960,
JSGG20160229195900623 and JCYJ20150402152005636), Sanming Project of
medicine in Shenzhen (SZSM20150602).
第一作者机构：[1]Department of Orthopaedics and Traumatology, People's Hospital of Bao'an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao'an District, Shenzhen, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Peng X,Wu X,Zhang J,et al.The role of CKIP-1 in osteoporosis development and treatment.[J].BONE & JOINT RESEARCH.2018,7(2):173-178.doi:10.1302/2046-3758.72.BJR-2017-0172.R1.
APA：
Peng X,Wu X,Zhang J,Zhang G,Li G&Pan X.(2018).The role of CKIP-1 in osteoporosis development and treatment..BONE & JOINT RESEARCH,7,(2)
MLA：
Peng X,et al."The role of CKIP-1 in osteoporosis development and treatment.".BONE & JOINT RESEARCH 7..2(2018):173-178
医学