机构：[a]School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.[b]Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China.[c]School of traditional Chinese medicine, Ningxia Medical University, Yinchuan 750004, China.[d]Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University, Yinchuan 750004, China.[e]Depterment of General Hospital of Ningxia Medical University, Yinchuan 750004, China.[f]School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou 510640, China.
Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines. This study was designed to enrich total flavonoids (TFF) from G. uralensis. The chemical profile of TFF was identified by HPLC and colorimetric assay. The TFF mainly contained liquiritin apioside, liquiritin, isoliquiritin apioside, liquiritigenin and isoliquiritigenin without glycyrrhizic acid. To study the anti-inflammatory activity of TFF, the DMB-induced ear vasodilatation assay and carrageenan-induced rat paw edema model have been utilized. Treatment with TFF showed significant anti-inflammatory activities in the two models. The two in-vivo edema assays demonstrated that the TFF possesses significant dose-dependent anti-inflammatory activity, similar to that of indomethacin at a dose of 500 mg/kg. In rat paws with carrageenan, treatment with TFF (500 and 250 mg/kg) markedly inhibited the expression of IL-1β and iNOS. TFF at all doses noticeably decreased levels of NO and MDA at the site of inflammation, while only i.g. TFF at a dose of 500 mg/kg significantly decreased TNF-α levels in the carrageenan-injected paws. In addition, an increase in SOD activity was induced by TFF at all doses. These results revealed that TFF exhibited significant anti-inflammatory activity in acute inflammatory models.
基金：
This work was supported by National Key
Technology R & D Program of China (Project
No 2011BAI05B01 and 2013BAI05B01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区药学
第一作者：
第一作者机构：[a]School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
共同第一作者：
通讯作者：
通讯机构：[a]School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.[b]Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China.[d]Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University, Yinchuan 750004, China.
推荐引用方式(GB/T 7714)：
Lei Yin,Enshuang Guan,Yuanbin Zhang,et al.Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch.[J].Iranian journal of pharmaceutical research : IJPR.2018,17(2):726-734.
APA：
Lei Yin,Enshuang Guan,Yuanbin Zhang,Zhiheng Shu,Bing Wang...&Meifeng Liu.(2018).Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch..Iranian journal of pharmaceutical research : IJPR,17,(2)
MLA：
Lei Yin,et al."Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch.".Iranian journal of pharmaceutical research : IJPR 17..2(2018):726-734
