机构：[1]Department of Anatomy, School of Basic Medical Science, Changchun University of Chinese Medicine, Changchun 130117, China[2]Department of Acupuncture, School of Acupuncture and Massage, Changchun University of Chinese Medicine, Changchun 130117, China[3]Laboratory of Function Science, Bethune School of Medical Science, Jilin University, Changchun 130021, China[4]Department of Histology & Embryology, Bethune School of Medical Science, Jilin University, Changchun 130021, China[5]Department of Histology & Embryology, Guangdong Medical College, Dongguan 523808, China[6]Orthopaedic Medical Center, Second Affiliated Hospital, Jilin University, Changchun 130041, China
The present study aimed to evaluate the role of the combination treatment of methylprednisolone (MP) and electroacupuncture (EA) in regeneration of nerve fibers and functional recovery in rats with spinal cord injury (SCI). Female Wistar rats were used for an SCI model by using a weight-drop hammer at levels T10 (spinal cord segment corresponding to the 10th thoracic vertebra). Four groups received different treatments for the study: SCI control, MP, MP and EA, and Sham. The growth of nerve fibers was examined by counting fluorescein positive nerve fibers. The motor functional recovery was evaluated by Basso, Beattie, Bresnahan (BBB) score, and electrophysiology analysis. We found that, compared to MP groups, there were more well-oriented and paralleled fluorescein positive nerve fibers in MP and EA group. Both latencies and amplitudes of the Motor Evoked Potential (MEP) in the combination therapy of MP and EA were higher than MP group. Additionally, recovered hindlimb movements were sustained in most rats in the MP and EA group. Our study indicated that combination therapies could become a powerful treatment for SCI in rats.
基金：
Chinese National Natural
Science Foundation, Contract Grant no. 30970739 (to Dong
Chen), and the National Basic Research Program of China,
Contract Grant no. 2014CB543100 (to Fu-ChunWang).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|3 区全科医学与补充医学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Department of Anatomy, School of Basic Medical Science, Changchun University of Chinese Medicine, Changchun 130117, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yi-Fan,Li Tie,Zhang Da-Wei,et al.The Comprehensive Therapy of Electroacupuncture Promotes Regeneration of Nerve Fibers and Motor Function Recovery in Rats after Spinal Cord Injury.[J].Evidence-based complementary and alternative medicine : eCAM.2018,2018:7568697.doi:10.1155/2018/7568697.
APA：
Li Yi-Fan,Li Tie,Zhang Da-Wei,Xue Hui,Chen Dong...&Wang Fu-Chun.(2018).The Comprehensive Therapy of Electroacupuncture Promotes Regeneration of Nerve Fibers and Motor Function Recovery in Rats after Spinal Cord Injury..Evidence-based complementary and alternative medicine : eCAM,2018,
MLA：
Li Yi-Fan,et al."The Comprehensive Therapy of Electroacupuncture Promotes Regeneration of Nerve Fibers and Motor Function Recovery in Rats after Spinal Cord Injury.".Evidence-based complementary and alternative medicine : eCAM 2018.(2018):7568697
