机构：[1]Department of Stomatology, Stomatological Hospital of Jingmen City, Jingmen, Hubei 448000[2]School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632[3]Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China华中科技大学同济医学院附属协和医院
Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer. The 5-year survival rate of OSCC is only ~50%. c-Myc is a known oncogene and target gene in various cancer types, including OSCC. The presnet study revealed that c-Myc is one of the target genes of miR-1294. Results indicated lower levels of miR-1294 in OSCC tissues samples collected from 24 patients with OSCC. Notably, overexpression of miR-1294 inhibited proliferation and migration in OSCC cell lines and inhibition of miR-1294 promoted cell growth and migration in OSCC cell lines. Moreover, miR-1294 can target the 3'UTR of c-Myc, as we identified a negative correlation between c-Myc mRNA expression and miR-1294 expression in 24 OSCC tissues. In conclusion, the data demonstrate the tumor suppressive role of miR-1294 in OSCC.
基金：
This work was supported by Funding of Hubei Province (grant no. 020716040026).
第一作者机构：[1]Department of Stomatology, Stomatological Hospital of Jingmen City, Jingmen, Hubei 448000
共同第一作者：
通讯作者：
通讯机构：[1]Department of Stomatology, Stomatological Hospital of Jingmen City, Jingmen, Hubei 448000[3]Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China[*1]Department of Stomatology, Stomatological Hospital of Jingmen City, 19 Changning Avenue, Dongbao, Jingmen, Hubei 448000, P.R. China[*2]Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430022, P.R. China
