资源类型：
期刊
WOS体系：
Article
Pubmed体系：
Journal Article;Research Support, Non-U.S. Gov't
收录情况：
◇ SCIE
文章类型：
论著
机构：
[a]Department of Chinese Medicine, Affiliated Longhua Central Hospital, Guangdong Medical University, Shenzhen, 518110, Guangdong, China
深圳市康宁医院
深圳医学信息中心
[b]Department of Quality Control, Affiliated Longhua Central Hospital, Guangdong Medical University, Shenzhen, 518110, Guangdong, China
深圳市康宁医院
深圳医学信息中心
[c]Department of Medical Laboratory, Affiliated Longhua Central Hospital, Guangdong Medical University, Shenzhen, 518110, Guangdong, China
深圳市康宁医院
深圳医学信息中心
ISSN：
0006-291X
关键词：
ABCC1
Hepatocellular carcinoma
miR-7-5p
KCNQ1OT1
Oxaliplatin resistant
摘要：
The underlying functions of long non-coding RNAs (lncRNAs) on chemoresistance in multiple cancers have been testified. However, the function and mechanism of lncRNAs on chemoresistance in hepatocellular carcinoma are still confused. In this study, we concentrated on the function and mechanism of KCNQ1OT1 on oxaliplatin resistance in hepatocellular carcinoma. Results showed that KCNQ1OT1 was significantly up-regulated in oxaliplatin-resistant HepG2 and Huh7 cells. Moreover, knockdown of KCNQ1OT1 inhibited the cell proliferation, migration, invasion and reduced the expression of drug-resistant gene (MRP5, MDR1, LRP1). Additionally, bioinformatics analysis and dual-luciferase reporter assay showed that miR-7-5p directly targeted the 3'-UTR of miR-7-5p and ABCC1 mRNA, indicating that KCNQ1OT1 regulated the expression of ABCC1 via endogenous sponging miR-7-5p. Conclusively, KCNQ1OT1 modulated oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ABCC1 axis, indicating a novel approach for the treatment of hepatocellular carcinoma.
Copyright © 2018 Elsevier Inc. All rights reserved.
基金：
This work was supported by the National Natural Science
Foundation of China (No. 81660755) and the Science and Technology
Project of Shenzhen of China (No. JCYJ20170307160524377).
被引次数：
48
WOS：
WOS:000444791600031
PubmedID：
29966655
中科院(CAS)分区：
出版当年[2017]版：
大类
|
3 区
生物
小类
|
4 区
生化与分子生物学
4 区
生物物理
最新[2025]版：
大类
|
4 区
生物学
小类
|
4 区
生化与分子生物学
4 区
生物物理
JCR分区：
出版当年[2016]版：
Q3
BIOPHYSICS
Q3
BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3
BIOCHEMISTRY & MOLECULAR BIOLOGY
Q3
BIOPHYSICS
影响因子：
2.5
最新[2023版]
2.7
最新五年平均
2.466
出版当年[2016版]
2.354
出版当年五年平均
2.371
出版前一年[2015版]
2.559
出版后一年[2017版]
第一作者：
Huiqin Hu
第一作者机构：
[a]Department of Chinese Medicine, Affiliated Longhua Central Hospital, Guangdong Medical University, Shenzhen, 518110, Guangdong, China
通讯作者：
Changchun Zeng
推荐引用方式(GB/T 7714)：
Huiqin Hu,Li Yang,Lijun Li,et al.Long non-coding RNA KCNQ1OT1 modulates oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ ABCC1 axis.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,503(4):2400-2406.doi:10.1016/j.bbrc.2018.06.168.
APA：
Huiqin Hu,Li Yang,Lijun Li&Changchun Zeng.(2018).Long non-coding RNA KCNQ1OT1 modulates oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ ABCC1 axis..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503,(4)
MLA：
Huiqin Hu,et al."Long non-coding RNA KCNQ1OT1 modulates oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ ABCC1 axis.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503..4(2018):2400-2406
