机构：[1]Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China[2]Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China[3]Department of Human andMolecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23220, USA
We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases and clarified the association between these cells and the patient clinical data.
Patients with rheumatic diseases and healthy controls were recruited. The clinical characteristics were obtained. The MDSCs and their subsets were marked with fluorescently labelled antibodies and were then analyzed with flow cytometry.
The patients included 31 with RA, 21 with AS, 14 with OA, 11 with SLE with arthritis, 13 with SLE without arthritis, 9 with Gout, 10 with HUA, and 25 healthy controls. The proportions of MDSCs, M-MDSCs, and G-MDSCs were higher in patients with RA than in healthy controls (6.56±6.77% versus 1.46±0.96%, 2.52±3.81% versus 0.35±0.35%, and 1.13±1.64% versus 0.18±0.14%; p<0.001). The same increased cells were also found in other patients. The proportions of MDSCs and M-MDSCs were mostly correlated with the patient's joint inflammation indexes and the disease activity. When other cell subsets were adjusted, the increased risk of arthritis was also obtained for M-MDSCs (adjusted OR=5.772; p=0.031).
The expansion of MDSCs and their subsets was correlated with the disease activity and joint inflammation in patient with different rheumatic diseases. The proportion of M-MDSCs was associated with the risk of arthritis in those populations.
基金：
National Natural Science Foundation of China (nos. 81628017 and 81573730), the
Natural Science Foundation of Guangdong Province (no.
2017A030313868), and the President Foundation of Nanfang
Hospital, Southern Medical University (nos. 2017Z020 and
2016C024).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Junqing,Chen Shixian,Wu Lisheng,et al.The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis.[J].BioMed research international.2018,2018:5474828.doi:10.1155/2018/5474828.
APA：
Zhu Junqing,Chen Shixian,Wu Lisheng,Wang Ran,Zheng Songyuan...&Li Juan.(2018).The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis..BioMed research international,2018,
MLA：
Zhu Junqing,et al."The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis.".BioMed research international 2018.(2018):5474828
