The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex.
机构：[1]Nanjing University of Chinese Medicine, First Clinical Medical College, Institute of Pediatrics of traditional Chinese Medicine, Qixia District, Nanjing, 210029, Jiangsu Province, China.[2]Nanjing University of Chinese Medicine, Institute of Chinese medicine literature, Qixia District, Nanjing, 210029, Jiangsu Province, China.[3]Shenzhen traditional Chinese Medicine Hospital, Pediatrics of traditional Chinese Medicine, Shenzhen, 518038, Guangdong Province, China.[4]Institute of Geriatrics, Shenzhen, 518035, Guangdong Province, China.
Rehmanniae radix preparata is extracted from wine-steaming the Rehmannia root, a scrophulariaceae plant. It has been used for thousands of years with effects of nourishing kidney-yin, benefiting essence and filling marrow based on traditional Chinese medicine (TCM) theory. Rehmanniae radix preparata has antioxidant, antisenescence, anti-inflammatory, and neuroprotective properties. It is the most popular Traditional Chinese medicinal compound (TCMC) used in attention deficit hyperactivity disorder (ADHD) therapy. However, few studies have been conducted exploring the effects and potential mechanisms of Rehmanniae radix preparata alone on ADHD. Recent studies have shown that Rehmanniae radix preparata inhibits spontaneous activity in mice, improves learning and memory in rats following thalamic arcuate nucleus injury, and exhibits antidepressant effects. Catalpol, an active component of Rehmanniae radix preparata, elevates brain-derived neurotrophic factor (BDNF), and attenuates neuronal apoptosis and energy metabolism failure. ADHD is characterized by hyperactivity-impulsivity and impairments in learning and memory. Its pathomechanism is closely related to structural abnormalities in the cortex that is mediated by dysfunction in neuronal development, apoptosis, and energy metabolism. We hypothesize that Rehmanniae radix preparata may be effective at treating ADHD by alleviating neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failure.
基金：
Tis study was supported by the National Natural Science
Foundation of China (no. 81503616), Science and Technology
Planning Project of Guangdong Province of China
(no. 2014A020221003), Project of Guangdong Province
Administration of Traditional Chinese Medicine (no.
20161218), Science and Technology Project of Shenzhen
(no. JCYJ20160428105935612), Project of Health and Family Planning Commission of Shenzhen Municipality (no.
201505019), and Project of Natural Science Research
in Jiangsu Provincial Colleges and Universities (no.
17KJB360004).
第一作者机构：[1]Nanjing University of Chinese Medicine, First Clinical Medical College, Institute of Pediatrics of traditional Chinese Medicine, Qixia District, Nanjing, 210029, Jiangsu Province, China.
通讯作者：
通讯机构：[3]Shenzhen traditional Chinese Medicine Hospital, Pediatrics of traditional Chinese Medicine, Shenzhen, 518038, Guangdong Province, China.[4]Institute of Geriatrics, Shenzhen, 518035, Guangdong Province, China.
推荐引用方式(GB/T 7714)：
Yuan Haixia,Yang Meng,Han Xinmin,et al.The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex.[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2018,2018:doi:10.1155/2018/3052058.
APA：
Yuan Haixia,Yang Meng,Han Xinmin&Ni Xinqiang.(2018).The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex..EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2018,
MLA：
Yuan Haixia,et al."The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex.".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018.(2018)
