机构：[1]Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, People’s Republic of China[2]State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa 999078, Macau[3]Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou 510630, People’s Republic of China
Reactions of La(NO3)3·6H2O with the polar, tritopic quaternized carboxylate ligands N-carboxymethyl-3,5-dicarboxylpyridinium bromide (H3CmdcpBr) and N-(4-carboxybenzyl)-3,5-dicarboxylpyridinium bromide (H3CbdcpBr) afford two water-stable metal-organic frameworks (MOFs) of {[La4(Cmdcp)6(H2O)9]}n (1, 3D) and {[La2(Cbdcp)3(H2O)10]}n (2, 2D). MOFs 1 and 2 absorb the carboxyfluorescein (FAM)-tagged probe DNA (P-DNA) and quench the fluorescence of FAM via a photoinduced electron transfer (PET) process. The nonemissive P-DNA@MOF hybrids thus formed in turn function as sensing platforms to distinguish conservative linear, single-stranded RNA sequences of Sudan virus with high selectivity and low detection limits of 112 and 67 pM, respectively (at a signal-to-noise ratio of 3). These hybrids also exhibit high specificity and discriminate down to single-base mismatch RNA sequences.
基金：
Guangdong Provincial
Department of Science and Technology of China
(2015A010105016), Guangdong Provincial Natural Science
Foundation of China (2015A030313284), Macao Science and
Technology Development Fund (MUST-SKL-2016-04), and
the Tertiary Education Services Office, Macau Special
Administrative Region.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区化学
小类|1 区无机化学与核化学
最新[2025]版：
大类|2 区化学
小类|1 区无机化学与核化学
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, People’s Republic of China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Shui-Ping,Zhao Wei,Hu Pei-Pei,et al.Lanthanum-Based Metal-Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences down to Single-Base Mismatch.[J].Inorganic chemistry.2017,56(24):14880-14887.doi:10.1021/acs.inorgchem.7b02107.
APA：
Yang Shui-Ping,Zhao Wei,Hu Pei-Pei,Wu Ke-Yang,Jiang Zhi-Hong...&Chen Jin-Xiang.(2017).Lanthanum-Based Metal-Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences down to Single-Base Mismatch..Inorganic chemistry,56,(24)
MLA：
Yang Shui-Ping,et al."Lanthanum-Based Metal-Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences down to Single-Base Mismatch.".Inorganic chemistry 56..24(2017):14880-14887
化学