机构：[1]Department of Oncology, The First Affiliated Hospital of Jinan University,[2]Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University,[3]Department of Central Laboratory, The First Affiliated Hospital of Jinan University,[4]Department of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis.
A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids.
A contrast-enhanced computerized tomography (CECT) scan of the chest demonstrated tumors in the right mediastinum and right pleura. Percutaneous right mediastinal pleural biopsy confirmed recurrent thymoma (WHO type B3, Masaoka stage IVb). Histopathologic examination of her skin lesions revealed GVHD-like erythroderma.
The patient received chemotherapy and local thoracic radiotherapy, as well as corticosteroids.
The eruptions gradually subsided with hyperpigmentation; however the patient eventually died of multiple organ failure.
GVHD-like erythroderma is an uncommon paraneoplastic disorder associated with thymomas. Though its pathogenesis still needs further research, prompt diagnosis and appropriate treatment can improve survival rate in patients.
基金：
National Natural Science Foundation of China (No.
81071751).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区医学：内科
最新[2025]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Department of Oncology, The First Affiliated Hospital of Jinan University,
通讯作者：
通讯机构：[3]Department of Central Laboratory, The First Affiliated Hospital of Jinan University,[4]Department of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.[*1]Department of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19, Nonglin Road, Yuexiu District, Guangzhou, Guangdong, 510080, China, Department of Central Laboratory, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, China
推荐引用方式(GB/T 7714)：
Gui Xiujuan,Zhu Xinhai,Guo Liangjun,et al.Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report.[J].Medicine.2017,96(49):e8877.doi:10.1097/MD.0000000000008877.
APA：
Gui Xiujuan,Zhu Xinhai,Guo Liangjun,Tan Guoqiang,Liu Yan...&Lin Shaoqiang.(2017).Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report..Medicine,96,(49)
MLA：
Gui Xiujuan,et al."Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report.".Medicine 96..49(2017):e8877
