机构：[1]Department of Laboratory Medicine, Shiyan Taihe Hospital, College of Biomedical Engineering, Hubei University of Medicine, Shiyan 442000, Hubei, China[2]Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA[3]National Center of Colorectal Disease, Nanjing Municipal Hospital of Chinese Medicine, The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Guangdong, Nanjing 210001, China[4]Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA[5]Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China[6]Department of Respiration, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China[7]Department of Complementary & Integrative Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA
Lipids play roles in membrane structure, energy storage, and signal transduction as well as in human cancers. Here we adopt lipidomics to identify plasma lipid markers for early screening and detection of lung cancer.
Using mass spectrometry, we profiled 390 individual lipids using training and validation strategy in a total of 346 plasma samples from 199 early NSCLC patients, including 113 adenocacinoma and 86 squamous cell cancers (SqCC), and from 147 healthy controls.
In the training stage, we found distinct lipid groups that were significantly distributed between NSCLC cases and healthy controls. We further defined a panel of four lipid markers (LPE(18:1), ePE(40:4), C(18:2)CE and SM(22:0)) for prediction of early cancer with a accuracy of 82.3% AUC (Area under ROC curve), sensitivity of 81.9% and specificity of 70.7% at the training stage and yielded the predictive power with accuracy (AUC,80.8%), sensitivity 78.7%, specificity 69.4% and in the validation stage.
Using lipidomics we identified several lipid markers capable of discerning early stage lung carcinoma from healthy individuals, which might be further developed as a quick, safe blood test for early diagnosis of this disease.
基金：
This project was supported by the NIH grant (1R21 CA164764), Bears Care Foundation and Hawaii Community Foundation to Youping Deng. Lipid analyses were conducted at the Kansas Lipidomics Research Center Analytical Laboratory. This work was also supported by the NIH Grant 5P30GM114737, the NIH Grant P20GM103466, the NIH Grant U54 MD007584 and the NIH Grant 2U54MD007601. Jin-song Yang was supported by the Medical Science Development Subject in Science and Technology Project of Nanjing (Grant No. ZKX13017), the Natural Science Foundation of Jiangsu province (No. BK20151086), the National Nature Scientific Foundation of China (No. 81673030). Wei Gu was funded by the Medical Science Development Subject in Science and Technology Project of Nanjing (Grant No. YKK13104), the Medical Science Development Subject in Science and Technology Project of Nanjing (Grant No. YKK14094), Jiangsu Provincial Special Program of Medicine Science (Grant No. BE2015611).
第一作者机构：[1]Department of Laboratory Medicine, Shiyan Taihe Hospital, College of Biomedical Engineering, Hubei University of Medicine, Shiyan 442000, Hubei, China[2]Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
共同第一作者：
通讯作者：
通讯机构：[1]Department of Laboratory Medicine, Shiyan Taihe Hospital, College of Biomedical Engineering, Hubei University of Medicine, Shiyan 442000, Hubei, China[3]National Center of Colorectal Disease, Nanjing Municipal Hospital of Chinese Medicine, The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Guangdong, Nanjing 210001, China[7]Department of Complementary & Integrative Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA
推荐引用方式(GB/T 7714)：
Zongtao Yu,Hankui Chen,Junmei Ai,et al.Global lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer.[J].ONCOTARGET.2017,8(64):107899-107906.doi:10.18632/oncotarget.22391.
APA：
Zongtao Yu,Hankui Chen,Junmei Ai,Yong Zhu,Yan Li...&Youping Deng.(2017).Global lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer..ONCOTARGET,8,(64)
MLA：
Zongtao Yu,et al."Global lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer.".ONCOTARGET 8..64(2017):107899-107906
医学