机构：[1]Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China[2]Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau, China[3]Guangzhou Family Planning Specialty Hospital, Guangzhou, China
This review aimed to focus on the recent progress of the understanding of the role of phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it has been increasingly recognized that PI3K plays an important role in PCOS whose pathogenesis is unclear. However, research continues into revealing the details of how PI3Ks are involved in developing PCOS. Previous studies have shown that activation of the PI3K-protein kinase B (Akt) signaling pathway has important effects on insulin resistance and endometrial cancer. Knowledge of the action of PI3K in PCOS might provide valuable information to further validate the pathogenesis of PCOS and suggest new methods of treatment.
基金：
The
study was supported by Guangdong Natural Science Foundation(
S2013010011984); Science and Technology Planning Project
of Guangdong Province (2014A020212237); Guangdong provincial
population and Family Planning Commission (20133071); Guangzhou
Municipal Science and Technology Innovation Council
(201510010290); and Traditional Chinese Medicine Bureau Of
Guangdong Province (2010247).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|3 区妇产科学3 区生殖生物学
最新[2025]版：
大类|4 区医学
小类|4 区妇产科学4 区生殖生物学
第一作者：
第一作者机构：[1]Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China[2]Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau, China[*1]Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 510010, China.
推荐引用方式(GB/T 7714)：
Tiantian Li,Hui Mo,Wenfeng Chen,et al.Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome.[J].Reproductive sciences (Thousand Oaks, Calif.).2017,24(5):646-655.doi:10.1177/1933719116667606.
APA：
Tiantian Li,Hui Mo,Wenfeng Chen,Li Li,Yao Xiao...&Ying Lu.(2017).Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome..Reproductive sciences (Thousand Oaks, Calif.),24,(5)
MLA：
Tiantian Li,et al."Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome.".Reproductive sciences (Thousand Oaks, Calif.) 24..5(2017):646-655
