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Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice.

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机构： [a]Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China [b]Research Centre for Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China [c]Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China [d]School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA 6009, Australia [e]The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia [f]The National Key Discipline and the Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China [g]Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine, Ninth People's Hospital, Shanghai 200011, China

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关键词： Neohesperidin Osteoclasts Osteoporosis Inhibition

摘要：

Excessive bone resorption by osteoclasts plays an important role in osteoporosis. Bone loss occurs in ovariectomised (OVX) mice in a similar manner to that in humans, so this model is suitable for evaluating potential new therapies for osteoporosis. Neohesperidin (NE) is a flavonoid compound isolated from citrus fruits. Its role in bone metabolism is unknown. In this study we found that neohesperidin inhibits osteoclast differentiation, bone resorption and the expression of osteoclast marker genes, tartrate-resistant acid phosphatase and cathepsin K. In addition, neohesperidin inhibited receptor activator of NF-κB ligand (RANKL)-induced activation of NF-κB, and the degradation of inhibitor of kappa B-alpha (IκBα). Furthermore, neohesperidin inhibited RANKL induction of nuclear factor of activated T-cells (NFAT) and calcium oscillations. In vivo treatment of ovariectomised mice with neohesperidin protected against bone loss in mice. The results suggest neohesperidin has anti-osteoclastic effects in vitro and in vivo and possesses therapeutic potential as a natural anti-catabolic treatment in osteoporosis. Copyright Â© 2016 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2016]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢 3 区细胞生物学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区内分泌学与代谢

第一作者：

第一作者机构： [a]Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China [b]Research Centre for Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China [c]Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China

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通讯作者：

通讯机构： [a]Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China [b]Research Centre for Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China [c]Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi 530021, China [d]School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA 6009, Australia [*1]Research Centre for Regenerative Medicine, Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, No. 6 Shuangyong Rd, Nanning, Guangxi, China. [*2]School of Pathology and Laboratory Medicine, M504, The University ofWestern Australia, QEII Medical Centre, Nedlands,WA 6009, Australia.

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Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice.

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